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PharmacologyPharmacologyof of locallocal anesthesiaanesthesiaandanditsitstoxicitytoxicity
By:By:Dr Dr 
. Salah Abdel-Fattah. Salah Abdel-Fattah
Assist. Prof.of AnesthesiaAssist. Prof.of AnesthesiaKFUKFU
 
 
LOCAL ANESTHETICS 
Local anesthetics aredrugs, whichreversibly block
generation, propagation and oscillations
 of electrical impulsesin the excitabletissues.
 
 
MECHENISM OF ACTION 
•Block nerve fiber conductionby actingdirectly on nerve membranes to inhibitsodium ion from crossing themembrane
 –Nerves cannot depolarize –Conduction of impulses is blocked
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03 / 18 / 2010This doucment made it onto the Rising List!
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