Mechanisms of actions of antimicrobial drugs

ميحرلا نحرلا ا مسب

•Strategies to combat microbes:

•Public health measures•Screening procedures, early detection•Vaccines•Drugs•Drugs therapy targets selective differences between microbes and host cells

Introduction

Selective targeting of microorganisms

•Targets unique to microbes & lack in host cells:•Bacterial cell wall contains peptidoglycan strandse.g. Penicillins ↓ cross linking of peptidoglycans•Fungal cell membrane contains ergosterole.g. Azole antifungals ↓ ergoserol synthesis•Targets similar to microbes & have quantitativedifferences from the host cells:•Different enzyme or receptor isoforme.g.trimethoprim inhibits bacterial DHFR & pyrimethamine inhibits malarial DHFR •For selective targeting

important to understandmechanisms of actions of drugs