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Jonathan Cachat's Documents
Three-Dimensional Neurophenotyping of Adult Zebrafish Behavior
Here, we generated temporal and spatial three-dimensional (3D) reconstructions of zebrafish locomotion, globally assessed behavioral profiles evoked by several anxiogenic and anxiolytic manipulations, mapped individual endpoints to 3D reconstructions, and performed cluster analysis to reconfirm behavioral correlates of high- and low-anxiety states.
Category:ResearchReads:418Uploaded:04 / 01 / 2011ShareAdd to collectionInternational Development In History - Case Study
Connections and Collisions within the Cultural Matrix of Human Thought
Category:(not categorized)Reads:733Uploaded:09 / 17 / 2010ShareAdd to collectionConnections & Collisions in the Cultural Matrix of Human Thought
Case Study: Modern European Intellectual History; 1500 - 1700 AD
Category:ResearchReads:615Uploaded:09 / 17 / 2010ShareAdd to collectionQui non proficit, deficit: Experimental models for ‘integrative’ research of affective disorders
Experimental models are an important tool for the study of biological mechanisms of psychiatric disorders. Although encouraging progress has been made in biological psychiatry of affective disorders, there remain numerous methodological, conceptual, and translational challenges in this ␣eld. Mounting clinical data support the view that psychiatric disorders as spectra, rather than as discrete or isolated illnesses. This requires new theories as well as new animal paradigms for “integrative” modeling of psychiatric disorders and their spectra. Here we discuss recent “integrative” experimental models and concepts that promise to advance translational research of affective disorders.
Category:(not categorized)Reads:412Uploaded:08 / 07 / 2010ShareAdd to collectionModeling withdrawal syndrome in zebrafish
The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses.
Category:ScienceReads:210Uploaded:08 / 07 / 2010ShareAdd to collectionAnalyzing habituation responses to novelty in zebrafish (Danio rerio)
Analysis of habituation is widely used to characterize animal cognitive phenotypes and their modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral research, their habituation responses have not been extensively investigated. Utilizing the novel tank test, we examine intra- and inter-session habituation and demonstrate robust habituation responses in adult zebrafish
Category:ScienceReads:299Uploaded:08 / 07 / 2010ShareAdd to collectionThe effects of chronic social defeat stress on mouse self-grooming behavior and its patterning
Stress induced by social defeat is a strong modifier of animal anxiety and depression-like phenotypes. Self-grooming is a common rodent behavior, and has an ordered cephalo-caudal progression from licking of the paws to head, body, genitals and tail.
Category:(not categorized)Reads:372Uploaded:08 / 07 / 2010ShareAdd to collectionModeling seizure-related behavioral and endocrine phenotypes in adult zebrafish
Larval zebrafish (Danio rerio) have recently been suggested as a high-throughput experimental model of epilepsy-related pathogenetic states. Here we use adult zebrafish to study behavioral symptoms associated with drug-evoked seizures. Experimental epilepsy-like states were evoked in zebrafish by exposure for 20min to three chemoconvulsant drugs: caffeine (250 mg/L; 1.3 mM), pentylenetetrazole (1.5 g/L; 11.0 mM) and picrotoxin (100 mg/L; 0.17 mM).
Category:(not categorized)Reads:773Uploaded:08 / 07 / 2010ShareAdd to collectionCharacterization of behavioral and endocrine effects of LSD on zebrafish.
Lysergic acid diethylamide (LSD) is a potent hallucinogenic drug that strongly affects animal and human behavior. Although adult zebrafish (Danio rerio) are emerging as a promising neurobehavioral model, the effects of LSD on zebrafish have not been investigated previously.
Category:ScienceReads:886Uploaded:08 / 07 / 2010ShareAdd to collectionUnderstanding behavioral and physiological phenotypes of stress and anxiety in zebrafish.
We further validate zebrafish models of stress by analyzing how environmental and pharmacological manipulations affect their behavioral and physiological phenotypes.
Category:(not categorized)Reads:1,478Uploaded:04 / 30 / 2010ShareAdd to collection
