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NI Medical Innovation Summit
June 15, 2010
MAGNETIC IRON DETECTOR
Mauro Marinelli
Physics Dept. University of Genova and INFN, Italy
marinelli@ge.infn.it320 433 0989
 
2
Assessment of the
body iron burden
is essential formanagement of
diseases producing systematic iron
overload
.
Long-term transfusion therapy
(thalassemia major or otheranemias) or
increased dietary iron absorption
(hereditaryhemochromatosis) provide excessive amounts of iron stored inthe endocrine organs, heart and liver leading to cardiacdisease, cirrhosis and even to death.The
liver needle biopsy
is an invasive method for themeasurement of liver-iron concentration, susceptible of largeerrors due to the heterogeneous distribution of iron depositionin the liver.
 
MagnetPickup
 B
 B B
The
magnetic field flux
, threaded with thepickup, is
slightly modified
by the
diamagnetic (mainly from water)
and
paramagnetic (iron)
properties of tissues
.
MID measures the
totaliron overload
present the
liver region
7
10
BBisysensitivitrequiredThe
Iron magnetic susceptibility
Magnetic susceptibility arises fromcompetition between the aligning effect ofthe applied field and thermal vibrations
.
TC)()mKgK1081.2(
35-
2Fe
p/
p
iron effective magnetic moment(Bohr magneton)
•
deoxyhemoglobin (Hb)p =
5.2-5.5
•
oxyhemoglobin (HbO8)p =
0
•
Ferritin-Hemosiderin ironp
≈
4
•
Ferric iron ion Fe
3+
p =
5.9
C~ 0.4 mg/cc normal value0.4
 –
1 mg/cclight overload> 2 mg/cc severe overloadfor
C = 0.5 mg/cc, p = 4, T = 310 K (37
°
C)the iron susceptibility is ~ 7 10
-7
of 00

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