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BURGER'S
MEDICINALCHEMISTRY
AND
DRUG
DISCOVERY
4 
Sixth EditionVolume3:Cardiovascular Agentsand Endocrines
Edited
by
Donald
J.
Abraham
Department of Medicinal ChemistrySchool of PharmacyVirginia Commonwealth UniversityRichmond, Virginia
WILEY
-
INTERSCIENCE
A
john Wiley and Sons, Inc., Publication
 
PREFACE
,
Editors, Editorial Board Members, andsixth edition, we devote
an
entire subsectionWiley and Sons have worked for threeof Volume
4
to cancer research; we have alsoa half years to update the fifth edition of reviewed the major published Medicinal
ger's
Medicinal Chemistry and Drug Dis
-
Chemistry and Pharmacology texts to ensure
wvery.
The sixth edition has several new and that we did not omit any major therapeuticunique features. For the
first
time, there
will
classes of drugs.
An
editorial board was consti
-
an online version of this major reference tuted for the first time to also review and sug
-
rk. The online version
will
permit updating gest topics for inclusion. Their help was
and
easy access. For the
first
time, all volumes greatly appreciated. The newest innovation inare structured entirely according to content this series will be the publication of an aca
-
and
published simultaneously. Our intention demic,
"
textbook 
-
like
"
version titled,
"
Bur
-
was
to provide a spectrum of fields that would ger's Fundamentals of Medicinal Chemistry.
"
new or experienced medicinal
chem-
The academic text is to be published about abiologists, pharmacologists and molecu
-
year after this reference work appears.
It
williologists entry to their subjects of interest also appear with soft cover. Appropriate and
as
well
as
provide
a
current and global per
-
key information
will
be extracted from the ma
-
spective
of drug design, and drug develop
-
 jor reference.There are numerous colleagues, friends,Our hope was to make this edition of and associates to thank for their assistance.Burger the most comprehensive and useful First and foremost is Assistant Editor Dr.published to date. To accomplish this goal, we John
Andrako,
Professor emeritus, Virginiaexpanded the content from
69
chapters
(5
vol
-
Commonwealth University, School of 
Phar-es)
by approximately
50%
(to over 100 macy. John and
I
met almost every Tuesdays in
6 
volumes). We are greatly in debt for over three years to map out and executethors and editorial board members the game plan for the sixth edition. His contri
-
icipating
in
this revision of the major ref 
-
bution to the sixth edition cannot be under
-
work in our field. Several new subject stated. Ms. Susanne Steitz, Editorial Programave emerged since the fifth edition ap
-
Coordinator
at
Wiley, tirelessly and meticu
-
Proteomics, genomics, bioinformatics, lously kept us on schedule. Her contributionmbinatorial chemistry, high
-
throughput was also key in helping encourage authors to
screening,
blood substitutes, allosteric effec
-
return manuscripts and revisions so we couldtors as potential drugs, COX inhibitors, the publish the entire set at once.
I
would also like
etatins,
and high
-
throughput pharmacology to especially thank colleagues who attended
are
only a few. In addition to the new areas, we the QSAR Gordon Conference in 1999 for veryhave filled in gaps in the fifth edition by in
-
helpful suggestions, especially Roy
Vaz,
John
cluding
topics that were not covered. In the Mason, Yvonne Martin, John Block, and Hugo
of 00

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