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Human Papillomavirus Vaccine
Report to the Minnesota Legislature 2008
Minnesota Department of Health
February 1, 2008

Commissioner\u2019s Office
625 Robert St. N.
P.O. Box 64975
St. Paul, MN 55164-0975
(651) 201-5000
www.health.state.mn.us

Human Papillomavirus Vaccine
February 1, 2008
For more information, contact: Kristen Ehresmann, Manager

Infectious Disease Epidemiology, Prevention and Control,
Immunization, Tuberculosis & International Health
Minnesota Department of Health
P.O. Box 64975
St. Paul, MN 55164-0975
Phone: (651) 201-550
Fax: (651) 201-5501

3
TDD: (651) 201-5797
As required by Minnesota Statute 3.197: This report cost approximately $13,745 to prepare, including staff time, printing
and mailing expenses.
Upon request, this material will be made available in an alternative format such as large print, Braille or cassette tape.
Printed on recycled paper.
HPV Vaccine: Report to the Minnesota Legislature
Table of Contents
Page

Executive Summary....................................................................................................... i Background................................................................................................................... 1 Epidemiology of Human Papillomavirus (HPV).......................................................... 1

What is HPV?............................................................................................................................. 1 How does HPV spread?.............................................................................................................. 2 Minnesota-specific disease information..................................................................................... 3

HPV Vaccine.................................................................................................................. 5

Efficacy....................................................................................................................................... 5
Limitations of HPV vaccines...................................................................................................... 5
Federal vaccine recommendations.............................................................................................. 6
Implementation of vaccine recommendations............................................................................ 6
Vaccine safety............................................................................................................................. 8
Background............................................................................................................................. 8

Cost and Cost-Effectiveness of Vaccine................................................................... 10
Recommendation and Summary of Issues............................................................... 13
Considerations that are favorable for a HPV mandate.......................................................... 14
Considerations for not supporting a mandate at this time..................................................... 14
Conclusion................................................................................................................... 15
Attachments................................................................................................................ 19
Attachment A: Human Papillomavirus (HPV) Minnesota Health Care Programs Performance

Improvement Project Proposal
Attachment B: The Minnesota Vaccines for Children Program
Attachment C: Human Papillomavirus Vaccine: What You Should Know

Graphs
Page

Graph 1: Trends in Cervical Cancer in Minnesota and the U.S. ....................................................3 Graph 2: Cervical Cancer in Minnesota and the U.S., 2000-2004.................................................4 Graph 3: Uptake of HPV Vaccine in Minnesota, 2007..................................................................8 Graph 4: History of Federal Vaccine Awards Minnesota, 1997-2007.........................................12

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