Autistic children (possibly 33%) can often be helped dramatically by an infusion of the intestinal
hormone secretin. The need and the beneficial response to secretin, I think, are dependent upon
the amount of damage to the duodenum and upper small intestine from whatever cause, and on
the stomach’s ability to produce adequate hydrochloric acid (HCl) for proper digestion. Since
these two things largely determine proper digestion, it is vital that both be present. Without
adequate HCl, secretin infusion can, at best, be only partially effective in restoring digestion and
proper physical and mental function. With proper HCl present, secretin infusion may be totally
unnecessary.

The path of autism is different for each child. Some are prone to seizures, some are not; some
behave aggressively while others are overly passive. However, children with autism and with
ADHD share several factors. There is a deep disturbance in their fatty acid metabolism that
impairs their utilization of amino acids, and often there is an imbalance in their electrolytes.
Electrolytes control what’s called membrane traffic—what goes in and out of cells. This means
that providing other nutritional supplements is relatively ineffective until the electrolyte (sodium-
potassium-magnesium-calcium) imbalance is corrected. The delicate balance of electrolytes also
controls the electrical activity within the brain. Additionally, there is often heavy metals
poisoning, their minerals and amino acids are deficient and/or imbalanced, their production of red
and white blood cells is irregular; they have a dysfunctional immune system, 80% suffer
mitochondrial disorders according to Dr. Colemen, George Washington University Hospital, 90%
suffer some degree of hypothyroidism, despite "normal" TSH readings (Raphael Kellman, MD),
83% suffer dysfunctional Phase 1 and 2 liver enzyme function, and 85% of autistic meet criteria
for malabsorption leading to a multitude of nutrient deficiencies (B. Walsh). Both the autistic and
the ADHD often suffer lymphoid modular hyperplasia (measles infection in the gut).

Samplings of immune data reveal that most of these autism-spectrum disorder (ASD) children
have atypical elevations of antibodies against otherwise common pathogens such as Epstein-Barr
virus, Cytomegalovirus, and/or Human Herpes Virus 6 (EBV, CMV, HHV6), and in some 30%,
elevated anti-measles antibodies indicative of chronic infection from measles vaccine—
Kawashima H, Mori T, Kashiwagi Y, Takekuma K, Hoshika A, Wakefield A; Department of
Paediatrics, Tokyo Medical University, Japan. "Complete IgE deficiency was seen in 10% of
patients. Almost 20% of the patients had either low or a complete lack of IgA, which is quite high
compared to the general population (1 in 700 to 1,000). About 25% of the subjects had IgG
subclass deficiency. About 25% of the patients had a deficiency of various subsets of
lymphocytes (e.g., CD3, CD4, and CD8 Killer T-Cells). In fact, almost 35% of these autistic
children had a deficiency in Natural Killer Cells. In general, the cytokines IL-2 and alpha-
interferon are increased, while IL-1 is normal"—Dr. Sudhir Gupta. Other test results suggest that
an alteration in the suppressor T-cell subset is associated with autism. Their immune system is
driving with no brakes!

There are three major classes of Immune Cell types: granulocytes, monocytes, and lymphocytes. Lymphocytes are divided into three subgroups: B-Cells, T-cells, and Natural Killer Cells. T-cells are divided into helper cells, suppressor cells, and cytotoxic CD8, Killer T-cells. T-helper cells are called CD4 cells. That is, they shows the CD4 glycoprotein on their surface. All these produce

cytokines, chemical messengers that tell the other cells what to do. The CD4+ lymphocyte helper
cell activities are divided into Th1 (Cell-mediated immunity—defense primarily against viral,
fungi, and protozoa) and Th2 (humoral immunity—helps the B-cell to produce antibodies). Th1
and Th2 represent two separate, counterbalancing, functions of the immune system, and problems
occur when they are out of balance. It's most revealing to learn that the same insult given to those
of different genetic makeup will cause some to have a Th1 response, whereas others will have a
Th2 response! The ratio of these two is determined by the balance of adrenal steroids, notably
cortisol and DHEA. Since cortisol is an antagonist of DHEA, stress-induced cortisol production
shifts the number of CD4+ lymphocytes to predominantly Th2 expression. When Th1 is
diminished, Th2 predominates leading to a host of chronic diseases. Conditions are pro viral, pro
candida. The chronic viral infection whether measles or other cannot be cleared as long as this
bias exists. Furthermore, candida can enhance Th2. This increases IgE, causing candida to really
flourish. IgE is productive of numerous allergies. So, if you have high IgE or numerous allergies,
suspect that candida and stress are at work. To reduce stress-produced cortisol by 49%, give the
child 100 mcg of chromium each day. A 45 minute massage (back rub?) will give a like reduction.
Raising glutathione levels has been shown to alter the cytokine balance in favor of a Th1 immune
response—"The immune system"). (Peterson JD et al., 1998).

In addition to stress-induced, immune suppression, the body’s natural defense system is also
susceptible to stress-induced malnutrition. When the body begins to suffer from stress-induced
malnutrition, the cells of the immune system are deprived of critical nutrients necessary for their
function. In addition to the macronutrients, myraid micronutrients that include zinc, selenium,
vitamins A, C, E, and B6, the amino acids glutamine, cysteine, and arginine, and Omega-3 and
Omega-6 fatty acids are known to be necessary for a functional immune system. It is vital to note
that MMR vaccine, and the chronic measles infection so often following, depletes the body of

Cell-mediated immunity (CMI) in many infants is probably low, and the vaccines lower CMI
further. One vaccine decreases CMI by 50%; two together by 70%. Three? Yet, repeated
immunizations with 3 vaccines simultaneously from 4 weeks to 12 or 18 months are given.
Repeat DPT is given at 12 months. All these triple vaccines markedly impair CMI, yet some
uninformed doctors, solely for convenience and profit give 10 viruses into these struggling
immune systems in one sitting! The longest safety trial of the triple vaccine (MMR, all live
attenuated viruses) was three weeks!

"The repeated use of vaccinations would tend to shift the functional balance of the immune
system toward the antibody-producing side (Th2), and away from the acute inflammatory
discharging side (the cell-mediated side or Th1). This has been confirmed by observation
especially in the case of Gulf War Illness: most vaccinations caused a shift in immune function
from the Th1 side (acute inflammatory discharging response) to the Th2 side (chronic auto-
immune or allergic response).

"The wise use of vaccinations would be to use them selectively, and not on a mass scale. In order
for vaccinations to be helpful and not harmful, we must know beforehand in each individual to be
vaccinated whether the Th1 function or the Th2 function of the immune system predominates. In
individuals in whom the Th1 function predominates, causing many acute inflammations because
the cellular immune system is overreactive, a vaccination could have a balancing effect on the
immune system and be helpful for that individual. In individuals in whom the Th2 function
predominates, causing few acute inflammations, but rather the tendency to chronic allergic or

autoimmune inflammations, a vaccination would cause the Th2 function to predominate even
more, aggravating the imbalance of the immune system and harming the health of that
individual"—Philip F. Incao, MD.

Multiple vaccinations, in shifting this delicate balance to a predominant Th2 response, favor the
development of atopy (asthma, eczema, hay fever, and food intolerances) and, perhaps,
autoimmunity through vaccine-induced, polyclonal activation leading to autoantibody production.
An increase in the incidence of childhood atopic diseases may be expected as a result of
concurrent vaccination strategies that induce a Th2-biased immune response.

The literature shows an association between antiviral vaccination and onset of childhood asthma.
We have noted that attenuation of viral target by conventional vaccine preparation does not
completely remove or degrade viral nucleic acids such as double-stranded RNA (dsRNA). It is
known that viral dsRNA can induce activation of a host’s antiviral protein kinase (PKR). We have
shown that activation of PKR by dsRNA leads to expression of Th2-type immune responses, e.g.
allergy and asthma.—Farhad Imani, M.D., David Proud, M.D.

The odds of having a history of asthma was twice as great among (DTP) vaccinated subjects than
among unvaccinated subjects (adjusted odds ratio, 2.00; 95% confidence interval, 0.59 to 6.74).
The odds of having had any allergy-related respiratory symptom in the past 12 months was 63%
greater among vaccinated subjects than unvaccinated subjects (adjusted odds ratio, 1.63; 95%
confidence interval, 1.05 to 2.54). The associations between vaccination and subsequent allergies
and symptoms were greatest among children aged 5 through 10 years.—Hurwitz, E.L.,
Morgenstern, H; UCLA School of Public Health, Department of Epidemiology, Los Angeles,
California.

One study published in the Journal of Infectious Diseases documented a long-term depressive
effect on interferon production caused by the measles vaccine. Interferon is a chemical produced
by lymphocytes (a type of white blood cell) that renders the host resistant to infection.
Vaccination of one-year-old infants with measles vaccine caused a precipitous drop in the level of
alpha-interferon produced by lymphocytes. This decline persisted for one year following
vaccination, at which time the experiment was terminated. Thus, this study showed that measles
vaccine produced a significant long-term immune suppression. This suppression lays the child
open to all sorts of infections.

For example: a study published in the American Journal of Public Health Investigators on
children who contracted polio, a total of 1,300 cases in New York City and 2,137 cases in the
remainder of New York State, discovered that children with polio were twice as likely to have
received a DTP vaccination in the two months preceding the onset of polio than were the control
children. More recently, in a polio epidemic in Oman, DTP vaccination caused the onset of
paralytic polio. The report in the British medical journal Lancet confirmed that a significantly
higher percentage of these children with polio (43% compared to 28% of controls) had received a
DTP shot within 30 days of the onset of polio. The DTP vaccine suppresses the body’s ability to
fight off the polio virus.

Usually then, the autistic child needs to boost Th1 cells. This can be done with Omega-3 fatty
acids [EPA at 1000 to 1500 mg a day (two to three teaspoons of CLO), and DHA between 1500 to
2500 mg a day (3 to 5 teaspoons of CLO or fish oil]. Extra Virgin Olive oil, that contains oleic
acid: 4 tablespoons a day of fresh oil that’s been refrigerated is very supportive of Th1. Vitamin
A, 25,000 IU (adults), with a lot of carotenoids, a lot of vegetables, carrots, and things like that.