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    Epigenetics in Cancer
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    Epigenetics in Cancer
    Unavailable
    Epigenetics in Cancer
    Ebook299 pages3 hours

    Epigenetics in Cancer

    By Wiley

    ()

    Currently unavailable

    Currently unavailable

    About this ebook

    Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the differences between monozygotic (identical) twins. Aberrant DNA methylation is also frequently associated with human aging and diseases, such as cancer.

    This collection of overviews and laboratory protocols provides crucial, distilled information about the roles of epigenetics in cancer development. The overviews are geared for research scientists who need to learn more about the current understanding of epigenetic variation in humans and how the processes of DNA methylation and histone modification are regulated. The protocols give step-by-step instructions on how to detect DNA methylation using various methods such as MAPit, CHARM (arrays) and methylation-specific PCR.

    This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the fields of genetics, genomics, and oncogenesis for students or interdisciplinary collaborators.

    Table of Contents:

    Introduction

    Epigenetic Variation in Humans
    eLS
    Jon F. Wilkins

    Genetic and Epigenetic Heterogeneity in Cancer
    eLS
    Joshua B. Stevens, Batoul Y. Abdallah, Steven D. Horne, Guo Liu, Steven W. Bremer and Henry H. Heng

    Techniques & Applications

    Mediators and Dynamics of DNA Methylation
    WIREs Systems Biology and Medicine
    Robert Shoemaker, Wei Wang and Kun Zhang

    DNA Methylation Alterations in Multiple Myeloma as a Model for Epigenetic Changes in Cancer
    WIREs Systems Biology and Medicine
    Amy Sharma, Christoph J. Heuck, Melissa J. Fazzari, Jayesh Mehta, Seema Singhal, John M. Greally and Amit Verma

    Ink4?-Arf Locus in Cancer and Aging
    WIREs Developmental Biology
    Charles J. Sherr

    Protocols

    Simultaneous Single-Molecule Mapping of Protein-DNA Interactions and DNA Methylation by MAPit
    Current Protocols in Molecular Biology
    Carolina E. Pardo, Russell P. Darst, Nancy H. Nabilsi, Amber L. Delmas and Michael P. Kladde

    Comprehensive High-Throughput Arrays for Relative Methylation (CHARM)
    Current Protocols in Human Genetics
    Christine Ladd-Acosta, Martin J. Aryee, Jared M. Ordway and Andrew P. Feinberg

    Methylation-specific PCR
    Current Protocols in Human Genetics
    Bradford Coffee

    LanguageEnglish
    PublisherWiley
    Release dateJul 12, 2013
    ISBN9781118734391
    Unavailable
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