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Genetic Damage Lead to Neoplastic Transformation

Genetic Damage Lead to Neoplastic Transformation

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Published by eka dharma

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Published by: eka dharma on Jul 28, 2012
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11/11/2014

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Genetic Damage Lead toNeoplastic Transformation
Chemical Carcinogens
Radiation
Viruses
 
Chemical Carcinogens
80-90% of human tumors are due to achemical carcinogens
 
Chemical Carcinogens:
Two main stage in overall process
Initiation:
The initiation step occurs when a cell isexposed to an appropriate dose of a carcinogenicagent (the initiator) and is altered in such a way that itis likely to give rise to a tumor. Process : Rapid andirreversible and due to DNA damage (mutation)
Promotion:
describes the step in which there isproliferation and clonal expansion of initiated cell.However, in contrast to initiator, PROMOTERS do notaffect the DNA directly and their effects are reversible.

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