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Black berry administration minimizes the toxic effects of sodium.pdf

Black berry administration minimizes the toxic effects of sodium.pdf

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Published by Juan GoldenBoy
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Published by: Juan GoldenBoy on Aug 01, 2012
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05/13/2014

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Abstract Source:
H A Hassan, A F Abdel-Aziz
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, , , , ,Egypt. drhanaahassan@yahoo.com
Abstract:
Oxidative damage to cellular components such as lipids and cell membranes by free radicals andother reactive oxygen species is believed to be associated with the development of degenerativediseases. Fluoride intoxication is associated with oxidative stress and altered anti-oxidant defensemechanism. So the present study was extended to investigate black berry anti-oxidant capacitytowards superoxide anion radicals, hydroxyl radicals and nitrite in different organs of fluoride-intoxicated rats. The data indicated that sodium fluoride (10.3mg/kg bw) administration inducedoxidative stress as evidenced by elevated levels of lipid peroxidation and nitric oxide in red bloodcells, kidney, testis and brain tissues. Moreover, significantly decreased glutathione level, totalanti-oxidant capacity and superoxide dismutase activity were observed in the examined tissues.On the other hand, the induced oxidative stress and the alterations in anti-oxidant system werenormalized by the oral administration of black berry juice (1.6g/kg bw). Therefore it can beconcluded that black berry administration could minimize the toxic effects of fluoride indicating itsfree radical-scavenging and potent anti-oxidant activities.
Pubmed Data
: Food Chem Toxicol. 2010 Aug-Sep;48(8-9):1999-2004. Epub 2010 May 22. PMID:20472017
Article Published Date
: Aug 01, 2010
Study Type : Animal StudyAdditional LinksSubstances
:Blackberry : CK(17) : AC(13)
Diseases
:Fluoride Toxicity : CK(142) : AC(40)
Pharmacological Actions
:Antioxidants : CK(3508) : AC(1292)
 
 
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