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AudreyWk5LectureB

AudreyWk5LectureB

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Categories:Types, School Work
Published by: Remiere Joie V. Aguilar on Jan 13, 2009
Copyright:Attribution Non-commercial

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06/14/2009

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1
When comparing two different RNA samples, the signal from thetwo samples needs to be normalized
On spotted arrays:The red and green channels arescanned and detected separately,with
independent scan parameters.
 Example
: Imagine the red signal is detectedwith much higher laser intensity &PMT settings …Array would look artifactually red.
On Affymetrics-type arrays:
Same principle
:
one sample-one array Need to adjust for overall array intensity
 
2
Yang et al. 2002
 NAR
‘center the distribution’
 
3

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