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Published by: Ozone Peter Jovanovic on Aug 05, 2012
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01/11/2013

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Restenosis is a reparative process in response to injury induced by angioplasty.This process can be temporarily classified into three phases:
Phase 1 – Recoil, which tends to occur within the first 24 hours.
Phase 2 – Mural thrombus are thrombi adherent to the vessel wall. (Mural thrombusformation with subsequent organization by connective tissue, which occurs withinthe first 2-3 weeks.) Blood clot is the final product of blood coagulation. Itis achieved via the aggregation of platelets that form a platelet plug.
Phase 3 – Smooth muscle cell activation, migration, and proliferation along with increased synthesis of the extracellular matrix which occurs within the first 3 months.Modern medicine is a discipline founded on the premise that humans can alleviatetheir suffering from disease by intervention (that, after the cause and the course of the disease). Over many years, humans developed diverse ways to interfere with diseases by using chemical, physical, mental, and most recently EBOO SAFEtechnology (Extra-corporeal Blood Oxygenation and Ozonation, Simple Access Fluid Extraction) aimed at improving the quality and duration of life.However, in the course of proactive interventions in diseases processes, undesired consequences are often produced while prompting to gain benefits. This experience led practitioners to be cautious to avoid harm prior to considering intervention. In today’s medicine, new interventions are required to establish a clinically acceptable “therapeutic Index” (meaning that benefit clearly must surpass any liabilities or harmful consequences to the patient).Ultimately, the whole enterprise of medical science and pharmacology is about safety and efficacy. Historians of private professional regulation have shown thatprofessional men and women built institutions to research test, certify and monitor drug purity and efficacy even before the FDA existed, (Ref: Burrow 1970, Dowling 1970, Sonnedecker 1970) (described the era prior to Federal government interventions) “Having relied on voluntary and democratic decision making for the creation of the pharmacopoeia, organized medicine and later organized pharmacy alsorelied on voluntary compliance. It thus seemed a characteristic American Venture of free and independent professions”.Thereupon, PPPOM (Pertubuhan Pengamal Perubatan Ozon Malaysia or The Organization of Malaysian Ozone Practitioners) is set up to inspect the quality and safetyof the seller’s product. PPPOM shall grant certification mark or seal of approvaland therefore it shall underwrite the charters of modern regulatory agencies, which seek safety and efficacy as the basis of drug and device approval for medical use. With this in mind, EBOO SAFE reflects the reality of medical interventional cardiology – mitigating the consequence of an old disease, atherosclerosis, while at the same time, eliciting a new pathology, restenosis. The need to relieveobstruction to blood flow in essential blood vessels such as the coronary arteries has led to novel and powerful intervention that produce rapid relief from life threatening events such as abrupt vessel obstruction. PTCA, stents, EBOO SAFEand other interventions have proven to be of a great benefit to patients in danger of death from myocardial infarction. In particular, the use of PTCA and stents is currently a common practice in many medical centers with a success ratio of 96%, and minimal hospitalization, timely morbidity and mortality. The only real shadow cast over their modern success in conquering coronary (and other vessel) obstructions and heart attacks is the phenomenon of restenosis, or is simply re-occlusion of vessels that have been successfully opened by direct mechanicalintervention.Restenosis is a new disease, one of the many that medicine has encountered en route to introducing physical (e.g. radiation) or chemical (drugs) agents for therapeutic use. Restenosis, however, was not a predicted liability (un-like consequences to chemotherapy or radiation) because the pathology underlying restenosisdiffers substantially from the pathology of the disease leading to obstruction of the blood vessel in the first place, namely, atherosclerosis and thrombosis. Restenosis is a significant medical problem because it occurs in a large proportion of patients (30-50%) undergoing PTCA or stent placements, which may result in

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