Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Standard view
Full view
of .
Save to My Library
Look up keyword
Like this
15Activity
P. 1
A New Way of Understanding Allergies and Autoimmune Diseases: AN EPIDEMIC OF ABSENCE

A New Way of Understanding Allergies and Autoimmune Diseases: AN EPIDEMIC OF ABSENCE

Ratings:

4.8

(5)
|Views: 512 |Likes:
Published by Simon and Schuster
Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn’s disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that’s because it has—to levels never before seen in human history. These days no fewer than one in five—and likely more—Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works.

In the past 150 years, improved sanitation, water treatment, and the advent of vaccines and antibiotics have saved countless lives, nearly eradicating diseases that had plagued humanity for millennia. But now, a growing body of evidence suggests that the very steps we took to combat infections also eliminated organisms that kept our bodies in balance. The idea that we have systematically cleaned ourselves to illness challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global “epidemic of absence,” they must restore the human ecosystem.

This groundbreaking book explores the promising but controversial “worm therapy”—deliberate infection with parasitic worms—in development to treat autoimmune disease. It explains why farmers’ children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease—that a mother’s inflammatory response imprints on her unborn child, tipping the scales toward allergy. In the future, preventive treatment—something as simple as a probiotic—will necessarily begin before birth.

An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.

An Epidemic of Absence considers the critical immune stimuli we inadvertently lost as we modernized, and the modern ills we may be able to correct by restoring them. At stake is nothing less than our health, and that of our loved ones. Researchers, meanwhile, have the good fortune of living through a paradigm shift, one of those occasional moments in the progress of science when a radically new way of thinking emerges, shakes things up, and suggests new avenues of treatment. You’ll discover that you’re not you at all, but a bustling collection of organisms, an ecosystem whose preservation and integrity require the utmost attention and care.

Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn’s disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that’s because it has—to levels never before seen in human history. These days no fewer than one in five—and likely more—Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works.

In the past 150 years, improved sanitation, water treatment, and the advent of vaccines and antibiotics have saved countless lives, nearly eradicating diseases that had plagued humanity for millennia. But now, a growing body of evidence suggests that the very steps we took to combat infections also eliminated organisms that kept our bodies in balance. The idea that we have systematically cleaned ourselves to illness challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global “epidemic of absence,” they must restore the human ecosystem.

This groundbreaking book explores the promising but controversial “worm therapy”—deliberate infection with parasitic worms—in development to treat autoimmune disease. It explains why farmers’ children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease—that a mother’s inflammatory response imprints on her unborn child, tipping the scales toward allergy. In the future, preventive treatment—something as simple as a probiotic—will necessarily begin before birth.

An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.

An Epidemic of Absence considers the critical immune stimuli we inadvertently lost as we modernized, and the modern ills we may be able to correct by restoring them. At stake is nothing less than our health, and that of our loved ones. Researchers, meanwhile, have the good fortune of living through a paradigm shift, one of those occasional moments in the progress of science when a radically new way of thinking emerges, shakes things up, and suggests new avenues of treatment. You’ll discover that you’re not you at all, but a bustling collection of organisms, an ecosystem whose preservation and integrity require the utmost attention and care.

More info:

Publish date: Sep 4, 2012
Added to Scribd: Aug 27, 2012
Copyright:Traditional Copyright: All rights reserved

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
Buy the full version from:AmazonBarnes & Noble
download as PDF, TXT or read online from Scribd
See more
See less

08/21/2013

pdf

text

original

 
unn
Mi|hi|}
M{ ?“G ^ [ ?M{ :“
@bgb ]qxoanlx}3
\ E O{ :?M{ =“N  O <8M{ <“[  @  D 5:M{ 8“T N O E2 0;M{ 5“Gd ‑B E‗ >>M{ 4“G G G ?:>M{ 0“\ L{{d Gj ?<<M{ >“M'T Ld ?5<M{ ?;“G{ ]3 T \ Iu M!   U!  J \ Ld ?>=M{ ??“G„ Lu{ L3 O  ]{d :?<M{ ?:“J Od  O3 N  L  Mus :<:M{ ?=“\ @ft Xd3 Mtd ‑\M  Od  N L :5=M{ ?<“A t  O G!   J„Ad Bd :0;M{ ?8“\ M{   ]{d!  T  LOj N :>:Oftd =;>I =?=] Jjd{ =88D =84
 
?
M@O[\HZ ?
Ghh| ^xz [ozo}n|h}
G!    d!  jd  !   f{         !   j    d     d     )
“Zj d!Jd {  Ij 
B  Iuj d! N    ] Ld   j'  ) \  c {{“ d !! {!  {“{    {d !  t    d {3   p j Gp) N  u {    j tf! {  N„  !  t {  @NU“ N„  d   d p{)O N u!      d     u  c! t N„ 3 t j d  jd!   {!   ) G   j! ddj! tu! { {  “t  dd ! j  d! t t !     ' ) O u d  u qd  d' tj) J N„ d  Gp {  j  c ! j )   c N„ j   ft
Ihmo|bz oghznmoix}
“ O “  j)O   j ! N„ { “    ,:!=;;) N N u t   { u! „ ,??8 {  { !       t ! t  d   O ) ] t“t '! N  “ ft t fd  't s!   t    d   )O {  {! t'  f   “tj  j   td“ t     !  ft 3 cd j!  !  ' p{  t ) \ {{      )

Activity (15)

You've already reviewed this. Edit your review.
misssusan_1 reviewed this
Rated 5/5
This is not a difficult book to understand. Anyone who suffers from these types of diseases, or knows someone who does, should read this book.
scrabblenut reviewed this
Rated 5/5
I would recommend this book to anyone with a background or interest in biology, as it is heavy on the science. That said, that is what makes the book great, as it doesn't gloss over things but gives us all the research, for and against the various theories that have been proposed about the huge increase in allergies and auto-immune diseases in our modern developed world with its emphasis on hygiene. Fascinating and informative, it includes the author's own experience with dosing himself with hookworms to try to overcome allergies.
1 thousand reads
1 hundred reads
trivian liked this
wjjera liked this
wjjera liked this
Dickson Ngaji liked this
Zwolf Wolfen liked this
Hector Sandoval liked this

You're Reading a Free Preview

Download
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->