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Nifedipine and Prednisone drug study

Nifedipine and Prednisone drug study

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Published by Phoebe Guevarra
GENERIC NAME Prednisone

BRAND NAME ApoPrednisone (CAN), Deltasone, Liquid Pred, Meticorten, NovoPrednisone (CAN), Orasone, Panasol-S, PrednicenM, PrednisoneIntensol, Sterapred DS, Winpred (CAN)

CLASSIFICATION Corticosteroid (intermediate acting), Glucocorticoid, Hormone

INDICATION - Replacement therapy in adrenal cortical insufficiency · Hypercalcemia associated with cancer · Short-term management of various inflammatory and allergic disorders, such as rheumatoid arthritis, collagen diseases
GENERIC NAME Prednisone

BRAND NAME ApoPrednisone (CAN), Deltasone, Liquid Pred, Meticorten, NovoPrednisone (CAN), Orasone, Panasol-S, PrednicenM, PrednisoneIntensol, Sterapred DS, Winpred (CAN)

CLASSIFICATION Corticosteroid (intermediate acting), Glucocorticoid, Hormone

INDICATION - Replacement therapy in adrenal cortical insufficiency · Hypercalcemia associated with cancer · Short-term management of various inflammatory and allergic disorders, such as rheumatoid arthritis, collagen diseases

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Published by: Phoebe Guevarra on Aug 27, 2012
Copyright:Attribution Non-commercial

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10/07/2013

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 GENERICNAMEBRANDNAMECLASSIFICATION INDICATION CONTRA
 –
INDICATIONDOSE,ROUTEFREQUENCYADVERSERXNNURSINGCONSIDERATION
Prednisone Apo-Prednisone(CAN),Deltasone,Liquid Pred,Meticorten,Novo-Prednisone(CAN),Orasone,Panasol-S,Prednicen-M,Prednisone-Intensol,SterapredDS, Winpred(CAN)Corticosteroid(intermediateacting),Glucocorticoid,Hormone- Replacementtherapy inadrenal corticalinsufficiency· Hypercalcemiaassociated withcancer· Short-termmanagement of variousinflammatoryand allergicdisorders, suchas rheumatoidarthritis, collagendiseases (eg,SLE),dermatologicdiseases(eg, pemphigus),statusasthmaticus, andautoimmunedisorders· Hematologicdisorders:thrombocytopeniContraindicatedwith infections,especiallytuberculosis,fungalinfections,amebiasis,vaccinia andvaricella, andantibiotic-resistantinfections;lactation.40-60 mg dailyfor 3-10 days;give as singleor in 2 divideddoses POVertigo, headache,paresthesias, insomnia,convulsions, psychosis,cataracts, increasedintraocular pressure,glaucoma (long-termtherapy)Hypotension, shock,hypertension and CHFsecondary to fluidretention,thromboembolism,thrombophlebitis, fatembolism, cardiacarrhythmiasNa+ and fluid retention,hypokalemia,hypocalcemiaAmenorrhea, irregularmenses, growthretardation, decreasedcarbohydrate tolerance,diabetes mellitus,cushingoid state (long-term effect), increasedblood sugar, increasedserum cholesterol,- Administer once-a-day doses before 9AM to mimic normalpeak corticosteroidblood levels.· Increase dosagewhen patient issubject to stress.· Taper doses whendiscontinuing high-dose or long-termtherapy.· Do not give live virusvaccines withimmunosuppressivedoses of corticosteroids.
 
a purpura,erythroblastopenia· Ulcerativecolitis, acuteexacerbations of multiple sclerosisand palliation insome leukemiasand lymphomas· Trichinosis withneurologic ormyocardialinvolvementdecreased T3 and T4levels, HPA suppressionwith systemic therapylonger than 5 daysPeptic or esophagealulcer, pancreatitis,abdominal distention,nausea, vomiting,increased appetite, weightgain (long-term therapy)Hypersensitivity oranaphylactoid reactions
 
 
GENERICNAMEBRANDNAMECLASSIFICATIONINDICATION CONTRA -INDICATIONDOSE,ROUTEFREQUENCYADVERSERXNNURSINGCONSIDERATION
Nifedipine Adalat, AdalatCC, Procardia,Procardia XLcardiovascularagent; calciumchannelblocker; antiarrhythmic(classiv); nonnitratevasodilator
-
Angina Pectorisdueto coronaryarteryspasm
-
Chronicunstableangina
-
SR preparationonly:Treatmentof hypertension.
-
Orphan drug use:Treatment of interstitialcystitis.Contraindicatedwith patientswho are allergicto nifedipine10-40 mg tabtwice daily PO
CNS:
 headache,asthenia,dizziness,fatigue,nervousness,sleepdisturbances.
CV:
 peripheral edema,angina,hypotension,arrhythmias, AV block,asystole
Dermatologic:
 Flushing, rash,pruritus,dermatitis
GI:
 nausea,Constipation, diarrhea,cramps,flatulence
OTHER:
 nasalcongestion,cough,fever, chills,shortnessof breath,musclecramps
 
 
Monitor BPcarefully duringtitration period.Patient maybecome severelyhypotensive,especially if alsotaking other drugsknown to lower BP.Withhold drug andnotify physician if systolic BP <90.
 
Monitor bloodsugar in diabeticpatients. Nifedipinehas diabetogenicproperties.
 
Monitor for gingivalhyperplasia andreport promptly.This is a rare butserious adverseeffect (similar tophenytoin-inducedhyperplasia).

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