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The synthesis of MPPF and CWAY-100635 analogues as PET tracers for 5HT1A receptors

The synthesis of MPPF and CWAY-100635 analogues as PET tracers for 5HT1A receptors

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An essay for the 2011 Undergraduate Awards Competition by Mary Brennan. Originally submitted for Chemistry Research Project at Trinity College, Dublin, with lecturer Wolfgang Schmitt in the category of Physical Sciences
An essay for the 2011 Undergraduate Awards Competition by Mary Brennan. Originally submitted for Chemistry Research Project at Trinity College, Dublin, with lecturer Wolfgang Schmitt in the category of Physical Sciences

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Published by: Undergraduate Awards on Aug 29, 2012
Copyright:Attribution Non-commercial

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10/27/2013

 
 
The Synthesis of MPPF and CWAY-100635 analogues as PET tracers for5HT
1A
receptors
NNNNOONO
2
F
[
18
F]MPPF
18
NNNNOONO
2
CWAY-100635
11
 
Abbreviations
Solvents:
 
CH
3
CN - AcetonitrileDMF-DimethylformamideDMSO-DimethylsulphoxideEtOH - EthanolTHF-TetrahydrofuranCH
2
Cl
2
- DichloromethaneMeOH- Methanol
 Materials:
EDC - 1-ethyl-3-(3-dimethylaminopropyl) carbodiimideHCTU -2-(6-Chloro-1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminiumhexafluorophosphate HOAt - 1-Hydroxy-7-AzabenzotriazoleHOBt
 – 
HydroxybenzotriazoleDIPEA-
 N 
,
 N 
-DiisopropylethylamineNEt
3
-
 
TriethylamineSOCl
2
 
 – 
Thionyl ChlorideLiAlH
4
- Lithium Aluminium HydrideNa
2
SO
4
 
 – 
Sodium SulfatePCl
3
 
 – 
Phosphorus TrichlorideNaOH
 – 
Sodium Hydroxide
 
 
General:
13
C-NMR
 – 
Carbon 13 nuclear magnetic resonanceEquiv. - Equivalent
 
1
H-NMR
 – 
Proton nuclear magnetic resonanceHRMS
 – 
High Resolution Mass SpectrometryHPLC/MS
 – 
High Performance Liquid Chromatography / Mass SpectrometryIR
 – 
InfraredTLC
 – 
Thin Layer Chromatography

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