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Multi-metric and analytical analysis of rectal toxicity in hypofractionated 3D-conformal radiotherapy treated prostate cancer patients

Multi-metric and analytical analysis of rectal toxicity in hypofractionated 3D-conformal radiotherapy treated prostate cancer patients

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An essay for the 2012 Undergraduate Awards (International Programme) Competition by James Coates. Originally submitted for Medical Physics at McGill University, with lecturer Robert Maglieri in the category of Medical Sciences
An essay for the 2012 Undergraduate Awards (International Programme) Competition by James Coates. Originally submitted for Medical Physics at McGill University, with lecturer Robert Maglieri in the category of Medical Sciences

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Published by: Undergraduate Awards on Aug 31, 2012
Copyright:Attribution Non-commercial

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11/12/2013

 
 
Multi-metric and analytical analysis of rectal toxicityin hypofractionated 3D-conformal radiotherapytreated prostate cancer patients
 
 1
Summary
This project provides a modeling insight into both analytical mechanistic models of toxicities and statisticalmulti-metric modeling of treatment dosimetry variables inducing these side effects. The study consisted of 151patients treated with higher than usual fraction size (hypofractionated) 66 Gy radiotherapy in 22 fractions. Thepatients had an average follow-up time of 49.5 months, with a standard deviation of 12.4 months. The toxicity wasrecorded as the highest observed toxicity during the follow up period. A separate modeling was performed for onlythe toxicity observed during the last follow-up. Both the GI and GU toxicities were scored using the CommonToxicity Criteria, version 3, scoring system. The observed incidence of Grade 2 or higher GI or GU toxicity wasfound to be 13%. Surprisingly, initial analysis did not indicate positive correlations between dosimetry and GI/GUtoxicity. The study is on-going and utilizing Monte Carlo recalculations, updated toxicity reports, and advancedmodeling to delineate the dosimetric effects.

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