This project provides a modeling insight into both analytical mechanistic models of toxicities and statisticalmulti-metric modeling of treatment dosimetry variables inducing these side effects. The study consisted of 151patients treated with higher than usual fraction size (hypofractionated) 66 Gy radiotherapy in 22 fractions. Thepatients had an average follow-up time of 49.5 months, with a standard deviation of 12.4 months. The toxicity wasrecorded as the highest observed toxicity during the follow up period. A separate modeling was performed for onlythe toxicity observed during the last follow-up. Both the GI and GU toxicities were scored using the CommonToxicity Criteria, version 3, scoring system. The observed incidence of Grade 2 or higher GI or GU toxicity wasfound to be 13%. Surprisingly, initial analysis did not indicate positive correlations between dosimetry and GI/GUtoxicity. The study is on-going and utilizing Monte Carlo recalculations, updated toxicity reports, and advancedmodeling to delineate the dosimetric effects.