Muscle contraction is an important part of locomotion and many other essentialfunctions. The Sliding Filament Model describes active shortening of musclesas the result of myosin crossbridges causing the myosin ﬁlaments to slide rela-tive to actin ﬁlaments. In this project, we optimise and accelerate a computersimulation of a neighbourhood of crossbridges which are treated as a dependentpopulation. We subsequently obtain novel results describing the eﬀects of morecompliant environments on the life of a population of crossbridges. Since theﬁlaments stretch when a force is applied, a movement appears to be producedacross them. Using existing ideas about how each crossbridge reacts to relativemovement of its two ends and current measurements of the compliance of theﬁlaments and attached crossbridges, we show that the dynamics of a populationof crossbridges along the myosin ﬁlament are aﬀected by interactions with itsneighbours and present evidence to suggest that a higher compliance leads to ashorter crossbridge lifespan. The stochastic model of this behaviour is time con-suming when executed on a large scale. We present an optimised version of thesimulation in a compiled language and demonstrate performance gains of ap-proximately 3000 times the original run time using acceleration and parallelism.From many long term runs of this simulation with our performance gains, weare able to present never before seen results to beneﬁt our understanding of muscle contraction.