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A-10-1-13-61c4ee2

A-10-1-13-61c4ee2

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Published by Flavio Bernardotti

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Published by: Flavio Bernardotti on Sep 01, 2012
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09/01/2012

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J. of Nuclear Sci. and Tech.
 5036-291388 
No. 50, pp. 29-36, 2010
 ﭘ
 
 ﮔ 
 -67 
*
1
 
 ﭘ
 
2
 
3
 
1
 
 ﭼ
34
 
1- 
 ﮕ 
 
 ﮕ ﮋﭘ ﭘ
 :836-14395-  2- 
 ﮕ 
 - 3- 
 ﮕ 
 
ﮋﭘ
 - 3- 
 ﮕ 
 
 - 
 ﭼ
:
 
 ﭘ 
 
(SPION)
 
 
 ﭘ 
 
 ﭘ 
 
 ﮔ 
 -67 
Ga]-SPION
67
[
 . 
 ﭘ 
 
 ﭼ
 
3
Fe
+
 
2
Fe
+
 2 1 . 
XRDTGADSCVSMHRSEMTEM
 
FT-IR
 . 
SPION
 
 ﮔ 
-67 ) 96% 
RTLC
(. 
 ﭘ 
 4 . 
 ﭘ 
Ga]-SPION
67
[
 24 
 ﭘ 
3
Ga
+
67
 
 ﮔ 
. . 
 ﮔ 
 
 ﮕ 
 
 ﭘ 
 
 ﭘ 
 .
 
 ﭘ 
 
 ﮔ  
 67  
 ﭘ 
 
Preparation and Biological Evaluation of [
67
Ga]-Labeled-SuperparamagneticIron Oxide Nanoparticles in Normal Rats
A.R. Jalilian*
1
, A. Panahifar
2
, M. Mahmoudi
3
, M. Akhlaghi
1
, A. Simchi
3,4
 
1- Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, AEOI, P.O. Box: 14395-836, Tehran-Iran
2- Department of Engineering and Technical, Science and Research Branch, Islamic Azad University, Tehran-Iran3- Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran-Iran4- Department of Material Science and Engineering, Sharif University of Technology, Tehran-Iran
Abstract:
 
Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([
67
Ga]-SPION) wereprepared and evaluated for their altered biodistribution in normal rats. SPIONs with narrow sizedistribution were synthesized by co-precipitation technique using ferric and ferrous salts at molar ratioFe
3+
 /Fe
2+
=2:1 followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM andFT-IR techniques. In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticleswere prepared using
67
Ga with a high labeling efficiency (over 96%, determined by RTLC method) andthey also showed an excellent stability at room temperature for at least 4 days. The biodistribution of theradiolabeled SPION was checked in normal male rats up to 24 hours compared with the free Ga
3+
cationbiodistribution. The data strongly support the alteration of the tracer accumulation in reticuluendothelialsystem while the stability of the complex is highly retained. The result is promising for determining theposition of the nanoparticles injected into a tissue when hyperthermia treatment/imaging is applied inbiomedical fields.
 Keywords:
Superparamagnetism, Iron Oxides, Gallium 67, Biodistribution, Labeled Compounds
:12/9/87
 ﭘ 
 :15/10/88 
ajalilian@nrcam.org*email:
 
 
 
 ﭘ 
. . . 
1- 
(SPION)
)1(
 
 ﭼ
 
 ﭘ 
 
 ﭘ 
 
 ﭘ 
 )
MRI
(
 ﮔ 
 
)2(
 
)3(
 . 
 ﭘ 
 
 ﭘ 
 
 ﮕ 
 . 
 ﮕ ﮔ 
 
]
1 6
[
. 30 
 ﭼ
 
 ﭘ 
. 
 ﭼ
 
 ﭼ
 
]
7
[
. . 
)4(
 -64
]
8
[
 ﭙ 
 -
m
99
]
9
[
 
]
10
[
 . -
 ﭼ
 -
 ﭼ
 .
 ﮔ 
) -  3 ( 
 ﭼ
 
 ﮔ 
. 
 ﮔ 
-67. 
 ﮔ ﭘ 
SPION
 
ﮋ 
 . 
2- 
1 
 ﮔ 
 -67
ﮋﭘ 
 
 ﭘ 
 
MeV
30 
Cyclone-30,IBA
 
 ﭘ 
 . 
 ﮕ 
 -
 ﮕ 
 
ﭻ 
 )
2
FeCl
,
3
FeCl
( . 
 ﭘ  ﭘ 
 
)5(
 
GC1020-7500SL
 
)6(
 .
 ﮔ 
 . 
 ﮔ 
 
 ﮔ 
 
Bio ScanAR2000
 . 
SPION 
 
ﮋ 
 
 ﮔ 
 1
/
0 ) .( 
2
FeCl
 
3
FeCl
 1 2
 ﮔ 
 
 ﮔ 
2
N
 .
 ﭼ
 
pH
8 . 
 ﭘ 
30 
 ﭘ 
 
 ﮔ 
. 
pH
 
 ﭼ
 . 
 ﭘ 
 ) ( 
 ﮕ 
 . 
 ﮔ 
 . 
 ﮔ 
 
]
11
[
. 
 
 501388 
Ga]-SPION 
67 
 [ 
 
SPION
 .
 ﮔ 
 -67  )2-5 
 ﮔ 
-67 
HCl
2
/
0(
 ﮔ 
 
2
N
 
 ﭙ 
 
 ﮔ 
 -67  . 
 ﮔ 
.
pH
 
HCl
 8
/
6 . 
 ﭘ 
 22
/
0 
 ﮔ 
 . 
 
1
Ga-SPION 
 
 ﮔ 
 .
 ﮕ 
TEM
 
ZEISS EM-10C
 
kV
100
HRSEM
 
FEG LECO
 . 
 ﮕ 
XRDSiemens D500
 
K
α
 
)7(
 
 ﭘ 
. 
 ﭘ 
 
ABB BomemMB-100
 .
 ﮔ 
TGA
 
DSC
 
 ﮕ  ﮔ 
 
DSC/TGA
 
SDT Q600,USA
 ﮔ 
 
. 30 
º
C
750 
C/min
10 
 
 ﮔ 
 
 ﮔ 
 . 
VSM
 ﮔ 
 .
 ﮕ 
 
VSM
 
3-
10)
emu
( 8  )66 (
 ﮔ 
. 
 
5 
Ga]-SPION
67
[
 
 ﮔ 
 1 
 ﮔ 
 // )2:4:4( 
 ﮔ 
 .
R
 
3
Ga
+
67
 
SPION
 9
/
0 0
/
0 )6.( 
 ﭘ 
 
Ga]-SPION 
67 
 [ 
 
 ﭘ 
Ga]-SPION
67
[
 ﮕ 
 
º
C
25 4 
RTLC
 
 ﭘ 
. 
 ﭘ 
 . 
 ﮔ 
 
ITLC
 . 
 
 ﭘ 
Ga]-SPION 
67 
 [ 
 
Ga
+
67 
 
 ﭘ 
 
Ga]-SPION
67
[
 
3
Ga]-GaCl
67
[
 
 ﮔ 
 
 ﮔ 
 .50-100 
Ga]-SPION
67
[
 9
/
0%
3
Ga
+
67
 )(
 ﭘ 
µCi
10 
 ﮔ 
. 
3
Ga
+
67
 
3
GaCl
-
Ga]
67
[
 ﮔ 
 
2
N
 
 ﭙ 
 9
/
0%
 ﮔ 
 . 
pH
 5
/
6. 1 24 
 ﭘ 
 
ﮋ 
 
 ﮔ 
 . 
3- 
1 
SPION 
 1 
TEM
 
HRSEM
 
SPION
 
 ﭘ 
 .
 ﮕ 
 
TEM
 15-
nm
25 . 2 
SPION
 . 
 ﭘ 
 
 ﭘ 
 )500-
1-
cm
1000( .
 ﮕ 
 
4
O
3
Fe
)
1-
cm
570( 
3
O
2
Fe
-
γ
) 
 ﭘ 
520-
1-
cm
610(
]
12
[
. 

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