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Notch signaling in the Immune System

Notch signaling in the Immune System

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Notch signaling plays a major role within the developing embryo. However its usefulness does not end there! Notch has also been linked to the development of immune cell, not only during embryonic development but also during the life of the organism. This essay attempts to sum up the contribution of notch signaling in immune cell development
Notch signaling plays a major role within the developing embryo. However its usefulness does not end there! Notch has also been linked to the development of immune cell, not only during embryonic development but also during the life of the organism. This essay attempts to sum up the contribution of notch signaling in immune cell development

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Published by: Undergraduate Awards on Sep 01, 2012
Copyright:Attribution Non-commercial

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09/25/2014

 
Notch Signalling in the Immune System.
Mini ReviewBy Darren RuaneBiochemistry with Immunology1
 
ContentsPage Title
3Abstract.4Introduction.5The Notch Receptor and its ligands.10The Notch Signalling Event.14Notch and Hematopoiesis.17Notch and T cells.24 Notch and TCR signalling in CD4CD8 SP thymocyte development. 25 Notch and peripheral T cell function.27 B cells and Notch. 30 Notch and NK cell development. 37 Concluding remarks.
Word Count: 9582
2
 
Abstract
The Notch signalling pathway (NSP) is a highly conserved signalling system, whichhas a role to play in cell differentiation and cell proliferation within the developingembryo. Notch signalling is also important in terms of the developing immunesystem, not only does it interact with immune progenerator cells but also cells of the peripheral immune system. Notch is required for the maintenance of hematopoieticstem cells and in directing T- versus B- fate decision. In addition to the classical work on Notch, recent developments such as the role of Notch in NK cell differentiationand activation will also be discussed.This review will summarize some of the most recent findings in relation to Notchfunction in our immune system during development and in the production andfunction of mature immune cells.3

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