Specific physical properties
Water permeability and water solubility: It determines the patterns of hydrolyticdegradation(bulk or surface) and rate of hydrolysis.
Polymer crystallinity: The crystallinity of the polymer is of importance since onlythe amorphous phase is susceptible to enzymatic attack.
Glass transition temperature: It has bearing on molecular chain mobility andpermeability characteristics of the polymer. The molecular chain mobilitydetermines the vulnerability of the polymer to enzymatic attack.
Physical dimensions: The physical components like size and surface to volumeratio are of significance in the biodegradation profile.
FACTORS AFFECTING BIODEGRADATION OF THE POLYMERS
Distribution of repeat units in multimers(4)
Presence of ionic groups(5)
Presence of chain defects or unexpected units(6)
Molecular weight distribution(9)
Morphology (amorphous/semi crystalline, microstructure, residual stresses)(10)
Presence of low molecular weight compound(11)
Presence of absorbed or adsorbed compounds (water, lipid, ions, etc.)(18)
Physicochemical factors (pH, ion exchange, ionic strength)(19)
Physical factors (change in shape and size, variations of diffusion coefficients,mechanical stresses, stress and solvent induced cracking)(20)