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Seminar on Biodegradable Polymers

Seminar on Biodegradable Polymers

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Published by: keyur on Sep 06, 2012
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06/07/2015

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1
ASEMINARONBIODEGRADABLEPOLYMERS
 
Keyur Vasava…
 
2
INTRODUCTIONDefinition
:
- Polymer comprised of monomers linked to one another through functional groupand have unstable linkage in the backbone.Biodegradable polymer degrading in biological fluidwith release of dissolved or dispersed drug.
 
Disadvantage of non biodegradable polymer
(1)
 
Surgical removal of drug depleted polymer is difficult.(2)
 
Toxic(3)
 
Not achieved constant rate of drug release.
Advantage of biodegradable polymers
(1)
 
Not require surgical removal of the drug.(2)
 
Breakdown products are natural and biocompatible. So, there is no toxicity.(3)
 
It give constant drug release.(4)
 
Localized delivery of drug(5)
 
Sustain delivery of drug(6)
 
Stabilization of drug(7)
 
Increase drug permeability
CHARACTERISTICS OF BIODEGRADABLE POLYMERS
 
It should be biocompatible
 
It should be biosorbable
 
It should be bifunctionl.
 
It should be stable
 
Predictability of biodegradation kinetics
 
Ease of fabrication
 
Absence of toxic endogenous impurities or residual chemicals used in there preparation.Eg. Cross linking agents
 
Achieve controlled heterogenous erosion without any additives
 
Acceptable shelf life
 
Ability to withstand the sterilization process
 
Degradation products that are excreted readily
 
Regulatory approval
 
3
Specific physical properties
 
Water permeability and water solubility: It determines the patterns of hydrolyticdegradation(bulk or surface) and rate of hydrolysis.
 
 
Polymer crystallinity: The crystallinity of the polymer is of importance since onlythe amorphous phase is susceptible to enzymatic attack.
 
 
Glass transition temperature: It has bearing on molecular chain mobility andpermeability characteristics of the polymer. The molecular chain mobilitydetermines the vulnerability of the polymer to enzymatic attack.
 
 
Physical dimensions: The physical components like size and surface to volumeratio are of significance in the biodegradation profile.
 
FACTORS AFFECTING BIODEGRADATION OF THE POLYMERS
(1)
 
Chemical structure(2)
 
Chemical composition(3)
 
Distribution of repeat units in multimers(4)
 
Presence of ionic groups(5)
 
Presence of chain defects or unexpected units(6)
 
Configuration structure(7)
 
Molecular weight(8)
 
Molecular weight distribution(9)
 
Morphology (amorphous/semi crystalline, microstructure, residual stresses)(10)
 
Presence of low molecular weight compound(11)
 
Processing condition(12)
 
Annealing(13)
 
Sterilization process(14)
 
Storage history(15)
 
Shape(16)
 
Implantation site(17)
 
Presence of absorbed or adsorbed compounds (water, lipid, ions, etc.)(18)
 
Physicochemical factors (pH, ion exchange, ionic strength)(19)
 
Physical factors (change in shape and size, variations of diffusion coefficients,mechanical stresses, stress and solvent induced cracking)(20)
 
Hydrolytic mechanism

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