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DRUG Nutrinet Interactions

DRUG Nutrinet Interactions

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Published by Dr. Heath Motley

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Published by: Dr. Heath Motley on Sep 07, 2012
Copyright:Attribution Non-commercial


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5HTP 5-hydroxytryptophan
5-HTP should be used with caution, if at all, in people taking selectiveserotonin reuptake inhibitors (SSRIs) and monoamine oxidaseinhibitors (MAOIs), two types of antidepressant medications.Specifically, the likelihood of developing unpleasant side effects,including serotonin syndrome (characterized by mental statuschanges, rigidity, hot flashes, rapidly fluctuating vital signs, andpossibly coma) is greater if you combine 5-HTP with the drugssumatriptan, tramadol, trazodone, venlafaxine, and zolpidem. Taking5-hydroxytryptophan with carbidopa, a medication used to treatParkinson's disease, has been associated with side effects, includingscleroderma-like illness (the skin becomes hard, thick, and inflamed).Using this combination should be avoided except under the supervisionof your healthcare provider.
Alpha-Linolenic Acid (ALA)
 The combination of alpha-linolenic acid (ALA) and lovastatin may offerbenefits to patients on lovastatin therapy. However, additional studiesin humans are needed to confirm these findings. You should consultwith your healthcare provider before taking ALA if you are currentlytaking lovastatin.
 The combination of aloe vera and glyburide, a medication used to treat Type II diabetes, may help control blood sugar and triglyceride levels inthe blood. However, you should not use aloe vera in these instanceswithout first consulting with your health care practitioner. Diabeticpatients using aloe vera either alone or in combination with otherantidiabetic medications need to be monitored closely by health careproviders to avoid potential complications from low blood sugar levels.Aloe vera may enhance the effects of hydrocortisone on swelling.Again, consult with your doctor before using aloe with hydrocortisonefor conditions involving inflammation or swelling.
Alpha-lipoic acid
In an animal study, alpha-lipoic acid supplements reduced side effects,particularly toxicity to the ear, associated with the antibiotics, amikacinand gentamicin. Additional studies are needed to confirm these effects
in humans. Similarly, the use of alpha-lipoic acid supplements inanimals protected against toxic side effects associated with the use of both cisplatin and cyclophosphamide. Consult with your healthcareprovider before taking alpha-lipoic acid supplements if you are takingany of these medications. Rats given alpha-lipoic acid supplementshad altered thyroid hormone function, but improved cholesterol levels. You would be wise to refrain from using alpha-lipoic acid supplementsexcept under the supervision of a healthcare provider. Blood hormonelevels and thyroid function tests should be monitored closely inpatients taking thyroid hormones, such as levothyroxine, with alpha-lipoic acid.
Astragalus may increase the effects of some antiviral medications suchas acyclovir and interferon. Astragalus may also counteract theimmune-suppressing effects of cyclophosphamide, a medication usedto reduce the chances of rejection in transplant recipients.
People taking the following medications should avoid beta-carotenesupplements:
Cholestyramine, Colestipol, Probucol
Cholestyramine and probucol, medications used to lower cholesterol,can lower blood concentrations of dietary beta carotene by 30% to40%, according to a 3-year trial in Sweden. Colestipol, a cholesterol-lowering medication similar to cholestyramin, may also reduce beta-carotene levels.
Beta-carotene and orlistat, a weight loss medication, should not betaken together because orlistat can reduce the absorption of beta-carotene by as much as 30%, thereby reducing the amount of thisnutrient in the body. Those who must take both orlistat and beta-carotene supplements should separate the time between taking themedication and the supplements by at least 2 hours.
In addition to these medications, mineral oil (used to treatconstipation) may lower blood concentrations of beta-carotene andongoing use of alcohol may interact with beta-carotene, increasing thelikelihood of liver damage.
Although black cohosh may act like the hormone estrogen, nonoteworthy interactions (positive or negative) between black cohoshand conventional medications, including hormone replacementtherapies, are known to have been reported in the literature to date.
Brewer's yeast contains a significant amount of tyramine, a substancethat should be avoided if you are taking a monoamine oxidase inhibitor(MAOI), a type of antidepressant. Examples of MAOIs are phenelzine,tranylcypromine, pargyline, selegiline, and isocarboxazid. Selegiline isalso used for the treatment of Parkinson's disease. Brewer's yeast mayalso interact with meperidine, a narcotic analgesic, used to treatintense pain. The dangerous interaction between brewer's yeast andthese medications may lead to "hypertensive crisis," a rapid andsevere increase in blood pressure that is characterized by
nausea andvomiting, headache, and irregular heartbeat.
This reaction mayresult in a heart attack or stroke.
In a clinical study, the combination of bromelain and amoxicillinincreased the levels of this antibiotic in the blood. Studies withbromelain and tetracycline have yielded mixed results regardingwhether bromelain increases the body's ability to absorb this antibiotic.More studies are needed to confirm these results. You should consultwith your healthcare provider before using bromelain if you arecurrently taking these antibiotics.
Although reports have shown that burdock has the ability to
lowerblood sugar
, no noteworthy interactions (positive or negative)between this herb and conventional medications (including antidiabeticmedications) are known to have been reported in the literature to date.

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