Academic Press is an imprint of Elsevier32 Jamestown Road, London, NW1 7BY, UKRadarweg 29, PO Box 211, 1000 AE Amsterdam, The NetherlandsLinacre House, Jordan Hill, Oxford OX2 8DP, UK30 Corporate Drive, Suite 400, Burlington, MA 01803, USA525 B Street, Suite 1900, San Diego, CA 92101-4495, USA

First edition 2008

2008 Elsevier Inc. All rights reserved.No part of this publication may be reproduced, stored in a retrieval systemor transmitted in any form or by any means electronic, mechanical, photocopying,recording or otherwise without the prior written permission of the Publisher.Permissions may be sought directly from Elsevier’s Science & Technology RightsDepartment in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333;email: permissions@elsevier.com. Alternatively you can submit your request online byvisiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting

Obtaining permission to use Elsevier material

.NoticeNo responsibility is assumed by the publisher for any injury and/or damage to personsor property as a matter of products liability, negligence or otherwise, or from any useor operation of any methods, products, instructions or ideas contained in the materialherein. Because of rapid advances in the medical sciences, in particular, independentverification of diagnoses and drug dosages should be made.ISBN: 978-0-12-374359-6ISSN: 0065-230XFor information on all Academic Press publicationsvisit our Web site at www.elsevierdirect.comPrinted and bound in USA08 09 10 11 10 9 8 7 6 5 4 3 2 1

Contributors

Numbers in parentheses indicate the pages on which the authors’ contributions begin.

Jay A. Berzofsky

, Vaccine Branch, Center for Cancer Research, NationalCancer Institute, National Institutes of Health, Bethesda, Maryland, USA(277)

Martin Cadogan

, Laboratory of Oncology, Department of Cellular andMolecular Medicine, St George’s University of London, London, UnitedKingdom (349)

Ashok K. Chakraborty

, Department of Dermatology and the Yale CancerCenter, Yale University School of Medicine, New Haven, Connecticut,USA (397)

Steven Y. Cheng

, Center for Cancer Research, Nanjing Medical University,Nanjing, Jiangsu, PR China (29)

Kimberly L. Christensen

, Program in Molecular Biology, University of Colorado School of Medicine, Denver, Colorado, USA (93)

Orly Cohen

, The Lautenberg Center for General and Tumor Immunology,The Institute of Medical Research, The Hebrew University, HadassahMedical School, Jerusalem, Israel (127)

Angus G. Dalgleish

, Laboratory of Oncology, Department of Cellular andMolecular Medicine, St George’s University of London, London, UnitedKingdom (349)

Heide L. Ford

, Department of Biochemistry and Molecular Genetics,University of Colorado School of Medicine, Denver, Colorado andDepartment of Obstetrics and Gynecology, University of Colorado Schoolof Medicine, Denver, Colorado, and Program in Molecular Biology,University of Colorado School of Medicine, Denver, Colorado, USA (93)

Federico Garrido

, Department of Analisis Clinicos e Inmunologia; HospitalUniversitario Virgen de las Nieves; Universidad de Granada, Granada,Spain (249)

Vi Luan Ha