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Sickle cell anemia

Sickle cell anemia

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Published by Sahar Iftar

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Published by: Sahar Iftar on Sep 12, 2012
Copyright:Attribution Non-commercial

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08/31/2013

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Dr Deepa Gupta Basu
Moderated by
 – 
Dr Harsha SoniDr AshokMohato
SICKLE CELLANAEMIA
 
Hb is a conjugated protein molecule consist of
two pairs of polypeptide chain. (alpha & beta)
Each globin chain bears a haem group whosecentral iron atom is the site to which O2
attaches to haemoglobin.
Molecular weight of Hb is 64000
 
 Hb A1-
97% of adult haemoglobin, consists of 2alpha & 2 beta chains.
 Hb A2-
Consists of 2 alpha & 2 delta chains.
 Hb F 
- 70
90% at birth, 25% by 1 month and 5%by 6months of age, consists of 2 alpha & 2 gammachains.
 Hb Gower 1
-Confined to embryonic stage, consistsof 2 alpha & 2 epsilon chains.
 Hb Gower 2
-Consists of 2 alpha & 2 zeta chains.
 Hb Portland-
Found in trace in neonates andintrauterine life.
 Hb
–Brat’s
Found in small amount in cord bloodof neonates with thalasseamia.

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