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ch8

ch8

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Published by Racky Sabido

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Published by: Racky Sabido on Sep 23, 2012
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01/02/2013

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Chapter 8Principles of Development
Donna May dela Cruz-PapaCollege of ScienceUniversity of Santo Tomas
 
Primary Organizer
 
Hans Spemann’s Research
 
only tissue to induce growth
Research in 1920
 –
1930scentered on: how one tissueinfluenced the fate of another:
induction 
1916 -
Spemann noted the capacity of tissuefrom the dorsal lip of the gastrula-transformed tissue
1921-22 -
Repeated delicate experiments showed itinduced a 2
°
embryo
All of the knowledge for constructing a complexegg must be in the nucleus and cytoplasm
 
 Advances in Molecular Biology
2
nd
golden age of embryology
Spemann organizer cells
 –
secrete proteins:1. Noggin2. Chordin3. Follistatin
Secretion of certain molecules trigger or repress theactivity of a combination of genes in nearby cells
Similar proteins occur in both invertebrates andvertebrates
These scientific breakthroughs ushered in the newscience of 
Evolutionary Developmental Biology

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