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How to use-CRP

How to use-CRP

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Published by: Alauddin Ahmed Jahan on Oct 01, 2012
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05/13/2014

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How to use: C-reactive protein
Arch Dis Child Educ Pract Ed 
2010;
95:
55-58
Compiled by Dr. Abu IqbalPaediatrics & Neonatology
 
CRP
CRP is a protein synthesised and secreted by the liver inresponse to inflammatory cytokines, particularly IL-6.
It plays this role by mediating
Phagocytosis
activating the complement cascade and by producing further inflammatory cytokines.
CRP forms complexes by binding to polysaccharides andpeptopolysaccharides present on bacteria
CRP also binds to components of damaged host cells
Ballou SP, Kushner I. Adv Intern Med 1992 Du Clos TW. Ann Med 2000 
 
Normal CRP
In normal individuals serum CRP is <10mg/l.
CRP is highly elevated by serious bacterialinfections (SBIs) up to 150
 –
350 mg/l, but
less highly elevated by acute viralinfection, to 20
 –
40 mg/l. However, someviral infections can cause elevations >100mg/l eg,
adenovirus,
mumps and
measles
Jaye DL, Waites KB. Pediatr Infect Dis J 1997 

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