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occurs when this precise system for regulating the kidneys' handling of fluids is disrupted.
1- frequent urination even at night, which can disrupt sleep and, on occasion, cause bedwetting.2-The large volume of urine is diluted, mostly water .3-To make up for lost water, patient may feel thirst .4-dehydration if they do not drink enough water.5- Children with DI may be irritable or listless and may have fever, vomiting, or diarrhea.
Types of Diabetes Insipidus “D.I.”: (4types)
Central DI(Neurogenic)Nephrogenic DI DipsogenicDIGestational DI
The most common form of serious DI.
It results from damage tothepituitary glandor hypothalamus, whichdisrupts the normalstorage and release of ADH that caused bydifferent diseases as wellas by ( head injuries,neurosurgery, or geneticdisorders).results when the kidneys areunable to respond to ADH. Thekidneys' ability to respond to ADH
can be impaired :-by drugs-like lithium ,for example.- by chronic disorders includingpolycystic kidney disease,sickle cell disease, kidneyfailure, partial blockage of theureters, chronic renalinsufficiency
and inherited geneticdisorders.-Sometimes the cause of nephrogenic DI is never discovered.by a defect in or damage to thethirstmechanism,which is locatedin thehypothalamus.This defectresults in anabnormalincrease in thirstand fluid intakethat suppresses ADH secretionand increasesurine output.occurs onlyduringpregnancyand resultswhen anenzyme madeby theplacentadestroys ADHin the mother.The placentais the systemof bloodvessels andother tissuethat developswith the fetus.The placentaallowsexchange of nutrients andwasteproducts