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Guidelines for the Management of Severe Traumatic Brain Injury 3rd Edition-1.2007

Guidelines for the Management of Severe Traumatic Brain Injury 3rd Edition-1.2007

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Published by: Cristy Herrera on Oct 11, 2012
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Journal of Neurotrauma
Section Editors
Charles H. Tator, M.D., Ph.D.
Clinical Management of Spinal Cord  Injury
 Division of NeurosurgeryUniversity of Toronto
Edward D. Hall, Ph.D.
 Neuroprotective and Neurorestorative Pharmacology
 Department of Anatomy and NeurobiologyUniversity of Kentucky–College of  Medicine
Douglas K. Anderson, Ph.D.
 Reorganization and Repair
 Department of NeuroscienceUniversity of Florida, College of  Medicine
David I. Graham, M.B., Ph.D.
 Department of Neuropathology Institute of Neurological SciencesSouthern General Hospital
Yoichi Katayama, M.D., Ph.D.
 Neurophysiology and Metabolism
 Department of Neurological Surgery Nihon University School of MedicineTokyo
Harvey Levin, Ph.D.
 Neuropsychology and Behavior
Physical Medicine & Rehabilitation Baylor College of Medicine
M. Ross Bullock, M.D., Ph.D.
Clinical Management of Brain Injury
 Medical College of Virginia Campus of Virginia Commonwealth University Richmond 
John F. Ditunno, Jr., M.D.
 Department of Rehabilitation MedicineThomas Jefferson University Hospital
John T. Povlishock, Ph.D.
VCU Neuroscience Center Virginia Commonwealth University Medical College of Virginia Campus1101 E. Marshall St.P.O. Box 980709 Richmond, VA 23298-0709(804) 828-9623Fax: (804) 828-9477  E-mail:
Australasian Editor
Yoichi Katayama, M.D., Ph.D.
 Department of Neurological Surgery Nihon University School of Medicine30-1 Oyaguchi-Kamimachi Itabashi-ku, Tokyo 173-8610 Japan81-3-3972-8111Fax: 81-3-3554-0425 E-mail:
Deputy Editor
M. Ross Bullock, M.D., Ph.D.
 Department of NeurosurgeryVirginia Commonwealth University Medical College of Virginia Campus1200 E. Broad St.P.O. Box 980631 Richmond, VA 23298-0631(804) 828-9165Fax: (804) 827-1693 E-mail:
European Editor
Lars T. Hillered, M.D., Ph.D.
 Department of Neuroscience, NeurosurgeryUppsala University HospitalSE-751 85 UppsalaSweden46-18-611-4969Fax: 46-18-558-617  E-mail:
Editorial Board
Andrew R. Blight, Ph.D.
 ACORDA Therapeutics, Inc. Hawthorne, NY 
Peter C. Blumbergs, M.D.
 Institute of Medical & Veterinary Science Adelaide, SA
Jacqueline C. Bresnahan, Ph.D.
Ohio State UniversityColumbus
Pak H. Chan, Ph.D.
Stanford University Medical Center 
Robert S. Clark, M.D.
Children’s Hospital of Pittsburgh
Guy L. Clifton, M.D.
University of Texas Medical School Houston
Douglas S. DeWitt, Ph.D.
University of TexasGalveston
W. Dalton Dietrich, III, Ph.D.
University of MiamiSchool of Medicine
C. Edward Dixon, Ph.D.
University of Pittsburgh
Michael Fehlings, M.D., Ph.D.
Toronto Western Hospital
Fred H. Gage, Ph.D.
The Salk Institute
M. Sean Grady, M.D.
University of Pennsylvania
Ronald L. Hayes, Ph.D.
University of FloridaCollege of Medicine
David A. Hovda, Ph.D.
University of California School of  Medicine Los Angeles
Chung Y. Hsu, M.D., Ph.D.
Taipei Medical UniversityTaiwan
Claire E. Hulsebosch, Ph.D.
University of Texas Medical BranchGalveston
John A. Jane, M.D., Ph.D.
University of VirginiaCharlottesville
Ji-yao Jiang, M.D., Ph.D.
Shanghai Jiaotong UniversitySchool of MedicinePeople’s Republic of China
Patrick M. Kochanek, M.D.
Critical Care MedicineSafar Center for Resuscitation ResearchPittsburgh
Morimichi Koshinaga, M.D., Ph.D.
 Nihon University School of MedicineTokyo
Bruce G. Lyeth, Ph.D.
University of California Davis
William L. Maxwell, Ph.D.
University of Glasgow
David F. Meaney, Ph.D.
University of Pennsylvania
R.J. Moulton, M.D.
St. Michael’s HospitalToronto
J. Paul Muizelaar, M.D., Ph.D.
University of California at Davis
Linda Noble, Ph.D.
University of CaliforniaSan Francisco
Claudia Robertson, M.D.
 Baylor College of Medicine
Kathryn Saatman, Ph.D.
University of Kentucky
Bernhard A. Sabel, Ph.D.
Otto-von-Guericke University of  MagdeburgGermany
Stephen W. Scheff, Ph.D.
University of Kentucky Lexington
Lisa Schnell, Ph.D.
University Zurich—Irchel
Esther Shohami, Ph.D.
The Hebrew University School of Pharmacy
Douglas Smith, M.D.
University of Pennsylvania Schoolof Medicine
Joe E. Springer, Ph.D.
University of Kentucky MedicalCenter  Lexington
Oswald Steward, Ph.D.
University of California Irvine
Robert Vink, Ph.D.
 Adelaide University Australia
Kevin K.W. Wang, Ph.D.
University of Florida
Stephen G. Waxman, M.D., Ph.D.
Yale University School of Medicine
Guidelines for the Management of Severe Traumatic Brain Injury 
3rd Edition
 A Joint Project of th
Brain Trauma Foundation
Improving the Outcome of Brain Trauma Patients Worldwide
 American Association of Neurological Surgeons (AANSCongress of Neurological Surgeons (CNS)  AANS/CNS Joint Section on Neurotrauma and Critical Car
Copyright ©2007 Brain Trauma Foundation, Inc. Copies are available through the Brain Trauma Foundation,708 Third Avenue, Suite 1810, New York, NY 10017-4201, phone (212) 772-0608, fax (212) 772-0357.Website: www.braintrauma.orgE-mail: btfinfo@braintrauma.org
General Information
is a treatment-oriented journal reporting rigorously reviewed experimental andclinical studies, concentrating on neurochemical, neurophysiological, and neuropathological research on spinal cordinjury, head trauma, peripheral neural injuries, and related neural injuries such as stroke.
(ISSN: 0897-7151) published (monthly) 12 times per year by Mary AnnLiebert, Inc., 140 Huguenot Street, 3rd Floor, New Rochelle, NY 10801-5215. Telephone: (914) 740-2100; fax:(914) 740-2101; e-mail: info@liebertpub.comOnline: www.liebertpub.com
Send address changesto
. Subscription Department, Mary Ann Liebert, Inc., 140 Huguenot Street, 3rdFloor, New Rochelle, NY 10801-5215. Mailed in Canada under CPM #40026674.
should be addressed to the Publisher and are payable in advance. Rates for subscriptions are for a vol-ume of 12 issues: USA print $1,241, International print $1,584, USA print and online $1,481, International print andonline $1,832, and online only (worldwide) $1,169. Subscriptions begin with the first issue of the current volume.Bulk subscriptions available upon request from the Publisher. No cancellations/refunds can be honored after publi-cation of a volume’s first issue. No refunds/returns on single issue purchases.
is owned and published by Mary Ann Liebert, Inc. Copyright
2007 by MaryAnn Liebert, Inc. Printed in the United States of America.See Instructions for Authors page for information on manuscript submission or visit our web site: www.liebertpub.com
Business Communications
should be addressed to the Publisher.
Advertising inquiries
from within the United States or Canada should be addressed to Catherine Hiller, Mary AnnLiebert, Inc., 140 Huguenot Street, 3rd Floor, New Rochelle, NY 10801-5215, (914) 740-2100. For Europe/ Outside the U.S., contact: Hilary Turnbull, imPRESS International Media Ltd., Carrington Kirk, Carrington,Midlothian EH 23 4LR, UK. Telephone:
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44(0)1875-825-701; e-mail: impress@im-pressmedia.comAll advertisements are subject to approval by the Publisher. The acceptance of advertisementsdoes not constitute an endorsement of the product or service advertised.
except special orders of 100 or more, are available from the authors. For permission to photocopy for in-ternal purposes 24 copies or less, please request permission and pay the appropriate fee by contacting the CustomerRelations Dept. of the Copyright Clearance Center, Inc., 22 Rosewood Drive, Danvers, MA 01923, 978-750-8400,fax: 978-750-4470. If the number of copies of an article is 25 or higher, contact the Publisher directly for options.
should be directed to the Editor-in-Chief, John T. Povlishock, Ph.D., Journal of Neurotrauma, VCUNeuroscience Center, Virginia Commonwealth University, Medical College of Virginia Campus, 1101 EastMarshall Street, Richmond, VA 23298, to the European Editor, Lars Hillered, M.D., Ph.D., Department of Neuroscience, Neurosurgery, Uppsala University Hospital, SE-751 85 Uppsala, Sweden, or the Australasian Editor,Yoichi Katayama, M.D., Ph.D., Department of Neurological Surgery, Nihon University School of Medicine, 30Oyaguchi-Kamimachi, Itabashiku-Tokyo 173, Japan.All papers, news, comments, opinions, findings, conclusions, or recommendations in
are those of the author(s), and do not constitute opinions, findings, conclusions, or recommendations of the Journal, its publisher, and its editorial staff.
is a
Journal Club
is indexed in
 MEDLINE, BIOSIS Previews, Current Contents/Life Sciences, EMBASE/Excerpta Medica, and Science Citation Index–Expanded.
The paper on which
is printed meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper). Printed on acid-free paper effective with Volume 14, Number 8, 1997.
Please visit us on the web: www.liebertpub.com

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