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Chemotherapy

Chemotherapy

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Published by KoRnflakes

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Published by: KoRnflakes on Jan 21, 2009
Copyright:Attribution Non-commercial

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11/09/2012

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CLASSIFICATION OF CHEMOTHERAPEUTICAGENTS
DRUG CLASS AND EXAMPLEMECHANISM OFACTIONCELL CYLCESPECIFICITYCOMMON SIDE EFFECTSALKYLATING AGENTS
Busulfan, carboplatin,chlorambucil,Cisplatin,Cyclophosphamide,dacarbazine,hexamethylmelamine,ifosfamide,melphalan,nitrogenmustard, thiotepaAlter DNAstructure by misreadingDNA code, initiating breaks in the DNAmolecule, cross-linkingDNA strands.Cell cycle-nonspecificBone marrow suppression, Nausea,vomiting,cystitis(cyclophosphamide,ifosfamide)stomatitis,alopecia,gonadalsuppression,renaltoxicity(cisplatin)
NITROSUREAS
Carmustine(BCNU),Lomustine(CCNU),Semustine(methylCCNU),StreptozocinSimilar to thealkylating agents;crossthe blood-brain barrier Cell cycle-nonspecificDelayed and cumulativemyelo-suppression,especiallythrombocytopenia;nausea,Vomiting
TOPOISOMERASE IINHIBITORS
Irinotican,tropotecan Induce breaks in theDNA strands by binding to enzymetopoisomeraseI,preventing cells fromdividingCell cycle-specificBone marrowsuppression,diarrhea,nausea,Vomiting,hepatotoxicity
ANTIMETABOLITES
5-Azacytadine,cytarabine,fludarabine,5-flourouracil(5-FU), FUDR,gemcitabine,hydroxyurea,leustatin,6-mercaptopurine,methotrexate,pentostatin,6-thioguanineInterfere with the biosynthesis of metabolites or nucleicacids necessary for RNA and DNAsynthesisCell cycle-specific(s phase) Nausea,vomiting,diarrhea, bone marrowsuppression,proctitis,stomatitis,renaltoxicity(methotrexate),hepatotoxicity

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