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For more information, write to Special Sales/Professional Marketingat the address below.This book is printed on acid-free paper.Copyright © 1997 by Marcel Dekker, Inc. All Rights Reserved.Neither this book nor any part may be reproduced or transmitted in anyform or by any means, electronic or mechanical, including photocopying,microfilming, and recording, or by any information storage and retrievalsystem, without permission in writing from the publisher.Marcel Dekker, Inc.270 Madison Avenue, New York, New York 10016Current printing (last digit):10 987654321PRINTED IN THE UNITED STATES OF AMERICA
The first edition of
Chromatographic Analysis of
waspublished in 1990. The past years have allowed me to evaluate leads that Iuncovered during the researching of the first edition, such as the first published example of the application of chromatography to pharmaceuticalanalysis of medicinal plants. This and other examples are found in a relatively rare book,
Anwendung in Pharmazeu-tichen Laboratorium
(Leipzig, 1992), by H. Platz. Capillary analysis, thechromatographic technique used, was developed by Friedlieb Runge in themid-1850s and was later refined by Friedrich Goppelsroeder. The principleof the analysis was that substances were absorbed on filter paper directlyfrom the solutions in which they were dissolved; they then migrated todifferent points on the filter paper. Capillary analysis differed from paperchromatography in that no developing solvent was used. We find that,from these humble beginnings 150 years ago, the direct descendant of thistechnique, paper chromatography, is still widely used in evaluating radiopharmaceuticals.This second edition updates and expands on coverage of the topics inthe first edition. It should appeal to chemists and biochemists in pharmaceutics and biotechnology responsible for analysis of pharmaceuticals. Asm the first edition, this book focuses on analysis of bulk and formulateddrug products, and not on analysis of drugs in biological fluids.