NIH Workshop: Regulation of Inflammatory Responses: Influence of Sex and Gender 1
Regulation of Inflammatory Responses:Influence of Sex and Gender
Bethesda, MarylandSeptember 19–20, 2006
WORKSHOP SUMMARY
Office of Research on Women’s Health, Office of the DirectorNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthDepartment of Health and Human Services
Workshop Co-Chairs
Lisa Begg, Dr.P.H., R.N., Office of Research on Women’s Health, Office of the DirectorChristopher E. Taylor, Sc.D., National Institute of Allergy and Infectious Diseases
NIH Workshop: Regulation of Inflammatory Responses: Influence of Sex and Gender 2
Seated (Left to Right): Esther M. Sternberg, Section on Neuroendocrine Immunology and Behavior, NIMH; DeLisaFairweather, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Edwin Deitch, Department of Surgery, New Jersey Medical School, Newark, NJ; Susan Kovats, Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; Michelle Petri,School of Medicine, Johns Hopkins University, Baltimore, MD; Daniel E. Furst, David Geffen School of Medicine,University of California, Los Angeles, Los Angeles, CA.Standing (Left to Right): Rhonda Voskuhl, Multiple Sclerosis Program, University of California, Los Angeles, Los Angeles, CA; Lisa Begg, ORWH; Chris Taylor, NIAID, Lester Kkobzik, Harvard School of Public Halth, Boston, MA;Steven Offenbacher, Peridontology Dental Research School of Dentistry, University of North Carolina at Chapel Hill,Chapel Hill, NC; Elizabeth J. Kovacs, Department of Surgery, Loyola Unive4rsity, Maywood, IL; Samuel N. Breit,Centre for Immunology, St. Vincent’s Hospital and University of New South Wales, Sydney, NSW, Australia ; Virginia M. Miller, Physiology and Surgery, Mayo Clinic, Rochester, MN; Godfrey S. Getz, Division of Pathology, University of Chicago, Chicago, IL; Greet van den Berghe, University of Leuven, Department of Intensive Care Medicine, University Hospital Gasthuisberg, Leuven, Belgium; Darryl C. Zeldin, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC; Jeff Bender, School of Medicine Yale University, New Haven, CT; [Not Shown: Peter Libby, Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA].
NIH Workshop: Regulation of Inflammatory Responses: Influence of Sex and Gender 3
Table of Contents
EXECUTIVE SUMMARY................................................................................................4Future Research..............................................................................................................5Research Considerations.................................................................................................5LIST OF ACRONYMS AND ABBREVIATIONS...........................................................7INTRODUCTION..............................................................................................................1SESSION I: INFLAMMATION: WHAT IS IT?...............................................................1An Overview of Inflammatory Mechanisms in Disease.................................................2Inflammatory Modulators of Cardiovascular Risk: Cause or Effect..............................4Hormones and Inflammation: Host-Pathogen-Hormone Interactions............................6SESSION II: SEX-RELATED INFLAMMATORY DISORDERS...................................8Estrogen Receptors and Autoimmune Disease...............................................................8Sex Differences in Inflammatory Responses to Shock/Trauma.....................................9Treatment of Burn Injury: Sex Effects..........................................................................10Sex Differences in Lung Function and Response to Environmental Agents................12Periodontal Disease Inflammation and Obstetric Complications.................................13SESSION III: CELLULAR AND MOLECULAR MECHANISMS ININFLAMMATION RESEARCH.....................................................................................15Vascular Cell Signaling by Membrane Estrogen Receptors.........................................15Sex Differences in Host Defense Against Pneumonia..................................................17Estrogen Modulation of Dendritic Cells.......................................................................18Estrogen, Inflammation, and Thrombotic Risk.............................................................19Use of Insulin Therapy in Treatment of Inflammatory Diseases..................................21SESSION IV: EMERGING STRATEGIES IN TREATMENT OF INFLAMMATORYDISEASES........................................................................................................................22TNF-Blocking Agents: Raising the Bar for Effective Treatment.................................22MIC-1, a Poorly Understood TGF-
β
Superfamily Cytokine with Roles in Inflammationand Cancer....................................................................................................................24Current Lupus Treatments Neither Control Disease Activity or Prevent Organ Damage:The Case for New Approaches.....................................................................................25IL-12 and Tim-3 Protect Against Coxsackievirus B3-induced Myocarditis................27SESSION V: PANEL DISCUSSIONS AND RECOMMENDATIONS.........................28Session I Discussion and Recommendations................................................................28Session II Discussion and Recommendations...............................................................28Session III Discussion and Recommendations.............................................................29Session IV Discussion and Recommendations.............................................................30Research Models and Other Research Considerations.................................................31CONTACT INFORMATION FOR CHAIRS AND SPEAKERS....................................33Chairs............................................................................................................................33Speakers and Session Moderators.................................................................................33LIST OF WORKSHOP ATTENDEES............................................................................36REFERENCES.................................................................................................................38
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National Institutes of Health: Inflammation Summary
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