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炎症与持久性有机污染物相关性代谢疾病间的潜在联系

炎症与持久性有机污染物相关性代谢疾病间的潜在联系

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流行病学研究显示,环境中的持久性有机污染物(POPs)可能会导致肥胖和代谢疾病特征的产生,比如甘油三酯水平偏高、葡萄糖耐受不良和心血管疾病。POPs包括二恶英类与呋喃类——其中2,3,7,8-四氯二苯并对二恶英(TCDD)在的效力最强——以及多氯联苯(PCBs)。由于它们的亲脂性,这些化合物聚积在脂肪组织中,这些部位许多内分泌和代谢功能会受到肥胖和代谢疾病的干扰。一项新的研究概述了一种机制,炎症通过这种机制能够在POP相关的代谢疾病中起到至关重要的作用[EHP 120(4):508–514;Kim等]。
流行病学研究显示,环境中的持久性有机污染物(POPs)可能会导致肥胖和代谢疾病特征的产生,比如甘油三酯水平偏高、葡萄糖耐受不良和心血管疾病。POPs包括二恶英类与呋喃类——其中2,3,7,8-四氯二苯并对二恶英(TCDD)在的效力最强——以及多氯联苯(PCBs)。由于它们的亲脂性,这些化合物聚积在脂肪组织中,这些部位许多内分泌和代谢功能会受到肥胖和代谢疾病的干扰。一项新的研究概述了一种机制,炎症通过这种机制能够在POP相关的代谢疾病中起到至关重要的作用[EHP 120(4):508–514;Kim等]。

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Published by: Environmental Health Perspectives on Oct 30, 2012
Copyright:Attribution Non-commercial

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07/16/2014

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