Hematopoietic System Introduction: Introduction
Blood supplies cells with water, electrolytes, nutrients, and hormones, and removeswaste products. The cellular elements supply oxygen (red blood cells), protect againstforeign organisms and antigens (white cells), and initiate coagulation (platelets).Because of the diversity of the hematopoietic system, its diseases are best discussedfrom a functional perspective. Function may be classified as either normal responses toabnormal situations (eg, leukocytosis and left shift in response to inflammation) or primary abnormalities of the hematopoietic system (eg, pancytopenia from marrowfailure). Furthermore, abnormalities may be quantitative (ie, too many or too few cells)or qualitative (ie, abnormalities in function).
the immune system,
Red Blood Cells
The function of red blood cells (RBC) is to carry oxygen to the tissues at pressuressufficient to permit rapid diffusion of oxygen. This is done by a carrier molecule,hemoglobin (Hgb); a vehicle (RBC) capable of bringing the intact Hgb to the cellular level; and a metabolism geared to protect both the RBC and the Hgb from damage.Interference with synthesis or release of Hgb, production or survival of RBC, or metabolism causes disease.Hgb is a complex molecule,formed of four heme units attached to four globins (twoα and two βglobins).Iron is added in the last step by the ferrochelatase enzyme. Interference with the normal production of heme or globin leads to anemia. Causes include copper or iron deficiencyand lead poisoning. Hemoglobinopathies such as thalassemias and sickle cell anemia,important genetic diseases of man, have not been seen in other animals. In thesediseases, the production of globins (α or β, or both) does not balance heme production,and the Hgb is not functional. The only known hemoglobinopathy of animals is porphyria. Although described in several species, it is most important as a cause of photosensitivity in cattle (
).Red cell mass, and thus oxygen-carrying capacity, remains constant over time in thenormal animal. Mature RBC have a finite life span; their production and destructionmust be carefully balanced, or disease ensues.Erythropoiesis is regulated by erythropoietin, which increases in the presence of hypoxia and regulates RBC production. In most species, the kidney is both the sensor organ and the major site of erythropoietin production, so chronic renal failure isassociated with anemia. Erythropoietin acts on the marrow in concert with other humoral mediators to increase the number of stem cells entering RBC production, toshorten maturation time, and to cause early release of reticulocytes. Other factors thataffect erythropoiesis are the supply of nutrients (such as iron, folate, or vitamin B
) andcell-cell interactions between erythroid precursors, lymphoid cells, and other components of the hematopoietic microenvironment. Factors that may suppress