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REGULATION OFCARDIAC FUNCTION
 
A. INTRINSICREGULATION
 
•
 The amount of blood pumped bythe heart each minute (
cardiacoutput
) is determined by the rateof blood flow into the heart fromthe veins (
venous return
)
 
STARLING’S LAW OF THEHEART
•
“ The mechanical energy set free onpassage from the resting to the contractedstate is a function of the length of themuscle fiber..”
•
Increasing the resting muscle fiber length, as withincreasing end-diastolic volume, will result in anincreased force of contraction manifested as anincreased peak pressure and increased strokevolume
•
 The reverse will be true if fiber length or end-diastolic volume is decreased
•
Also called
Heterometric Autoregulation
orintrinsic regulation due to changing length of cardiac muscle fiber
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Mijeroh

Please may I have a copy of your document for my personal use I am Biomedical Science Student.

reply12 / 04 / 2009
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