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Silica Nanoparticles as Drug Delivery System for Immunomodulator GMDP

Silica Nanoparticles as Drug Delivery System for Immunomodulator GMDP

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Published by Momentum Press
One of the ways of making drug delivery more efficient is the use of nanosystems for targeted delivery and timed release. This new monograph in the ASME-Momentum Press series on Biomedical & Nanomedical Technologies will explore the latest research on nanoparticulate delivery systems for the immune modulating agent, GMDP (N-acetylglucosaminyl-N-acetylmuramyl-Lisoglutamine), an important component in cell wall structure and receptors.
One of the ways of making drug delivery more efficient is the use of nanosystems for targeted delivery and timed release. This new monograph in the ASME-Momentum Press series on Biomedical & Nanomedical Technologies will explore the latest research on nanoparticulate delivery systems for the immune modulating agent, GMDP (N-acetylglucosaminyl-N-acetylmuramyl-Lisoglutamine), an important component in cell wall structure and receptors.

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Published by: Momentum Press on Nov 13, 2012
Copyright:Traditional Copyright: All rights reserved

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01/05/2014

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E.V. ParfenyukN.A. Alyoshina Yu.S. AntsiferovaN.Yu. Sotnikova
Silica Nanoparticlesas Drug DeliverySystem forImmunomodulatorGMDP
BIoMeDIcal & NaNoMeDIcal TechNoloGIeS
coNcISe MoNoGraPh SerIeS
 
Contents
Ii 11. D ivy y  pii   hiy  ii. Sii pi  pi i. 32. Syh  p ii i. 8
2.1 Syntheses o unmodied silica materials 82.2 Synthesis o modied silica materials 10
3. Chizi  ii i  pi i GMDP. 12
3.1 Characterization o silica materials via FIR spectroscopy 123.2 Characterization o silica materials via nitrogenadsorption–desorption measurements 143.3 Particle size o silica materials 193.4 Characterization o silica materials via small angle x-rayscattering (SAXS) 213.5 Adsorption properties o silica materials 213.6 DSC study o composites o model protein with silicamaterials 263.7 Calorimetric study o adsorption o model protein onsilica materials 293.8 Preparation o silica nanoparticle suspensions 33
4. Ii  ii pi ih i y . 35
4.1 Intensity o dierent silica nanoparticles uptake byimmune cells 354.2 Infuence o silica nanoparticles on parameters o unctionalactivity o peritoneal macrophages 41
5. Pi ph   ih ii pi   iy . 44
5.1 Impairment o peritoneal macrophage unctionat endometriosis 445.2 Infuence o glucosaminyl muramyldipeptideupon unctional activity o peritoneal macrophageso women with endometriosis 48
 
Contents6. Efiv  if yp  ii pi  i  pi ivy  GMDP i pi ph   ih ii. 51
6.1 Immobilization o GMDP on silica nanoparticles 516.2 Comparative study o the eects o ree GMDP and GMDimmobilized on silica nanoparticles on the unctional stateo peritoneal macrophages 52
R 59

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