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Performance on drugs

Performance on drugs

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Published by Kelly-Jane Doyle
Enhanced performance as a result of taking illegal substances banned from competition such as the olympics
Enhanced performance as a result of taking illegal substances banned from competition such as the olympics

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Published by: Kelly-Jane Doyle on Nov 15, 2012
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12/04/2012

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The Future of Performance-Enhancing Substances in SportSection: GUEST EDITORIALAthletes have used performance-enhancing substances (PESs) since ancient times,and still do.[1] Testing during the 2000 Tour de France revealed the presence of various performance enhancers (drugs and supplements alike) in the urine of 45 percent of competitors who were tested.[ 2] Furthermore, some of today's athletes use relatively simple medical techniques such as homologous and autologous bloodtransfusions to improve performance. Scientists may be inadvertently making it easier to circumvent drug tests by creating new delivery modalities such as patches and gelsto administer “old” drugs such as testosterone. This method provides stable levels of the drug in the blood rather than the “spikes” that follow injections, and thus reducesthe chance of positive tests.[3]The Use-Detection RaceAs the booming biotechnology and pharmaceutical industries discover new ways tofight disease, athletes and willing scientific advisers are also discovering ingeniousmeans to subvert those substances and to enhance performance and appearance. Someunscrupulous scientists attend academic meetings to gain insight into how substancescan be tweaked for athletic use. Then, a few months later, we hear rumors aboutathletes who are experimenting with these substances or notice that the compoundsare being sold as nutritional supplements. One possible example is Angiogenix. It is anicotine-based drug designed to help grow new blood vessels in cardiac patients, butit may also help athletes build muscle mass.[4] To what extent this drug is currently being used by athletes, or will be used in the future to enhance performances, isunknown. Another notable example involves the various scientific strategiesemployed to improve the performance of endurance athletes with compounds such aserythropoietin (EPO).Even as tests for detecting EPO were being developed, athletes and their scientificadvisers were already turning to other state-of-the-art replacements such as perfluorocarbon, which has the ability to dissolve a variety of gasses, includingoxygen, and actovegin, a derivative of calf serum used to increase the oxygen-carrying capacity of blood. Another tactic is to use compounds such as hydroxyethylstarch, a plasma volume expander that dilutes the concentrations of hemoglobin anderythrocytes. Hydroxyethyl starch can be used by athletes to avoid exceedinghemoglobin limits set by sports organizations, and authorities recently discovered thatthe compound had been used by Finnish cross-country skiers.[5]In addition, two cross-country skiers were stripped of their gold medals at this year'sContentsThe Use-Detection RaceBurgeoning New Products and Off-Label UsesCombating the ProblemDrug education programs, especially those that taaarget adolescent athletes, have the potential to change behavior and to be more cost-effective than it woulf be to further existing drug testing programs.Questions to Ponder REFERENCES
 
Olympics in Salt Lake City after testing positive for darbepoetin, a new recombinantversion of EPO.[6] It is no surprise then that a survey of participants in the 2000Olympic Games in Sydney revealed that athletes use an average of 6 to 7 PESs; onecompetitor was using 29![7]Some PESs, such as amphetamines, anabolic steroids, and diuretics, are banned bysport federations, while others are not, further illustrating the blurring of PESs that are“illegal” and those classified as dietary supplements (eg, sodium bicarbonate,creatine). A recent report from the International Olympic Committee (IOC) drugtesting lab in Cologne, Germany, has concluded that creatine, a ubiquitousendogenous energy source and dietary supplement, is a PES, and as such, should be banned, because it violates the IOC's medical code.[8]Burgeoning New Products and Off-Label UsesEven with new tests on the way, researchers say, there remains a panoply of PESs thatcannot be detected. A new generation of erythrocyte boosters produced from humanrather than animal cells and identical to the naturally occurring human EPO iscurrently making its way to the sports scene. Furthermore, in the rush to deploy newEPO tests, some tests may not have been adequately evaluated in peer-reviewed journals regarding validity, reliability, and replication. And, while EPO testing isfinally being instituted (although athletes can still resort to blood doping without fear of detection and get a similar effect), no reliable tests exist for recombinant humangrowth hormone and other purported performance boosters such as insulin-likegrowth factor-1.[9]A related issue is whether athletes are using medication for treating or cheating.Asthma products and other medicines were used by hundreds of athletes during the2000 Olympic Games in Sydney. About 6 percent of athletes produced waivers for asthma medication, but the incidence of asthma is about 1 percent in the general population.[10] As the World Anti-Doping Agency (WADA) Chairman Richard W.Pound remarked, “It's surprising how many of them are taking medications. You look at it and say, ‘How can all of the finest athletes on the face of the earth be so sick?’”[10]While estimates of PES use among elite athletes range widely and researchers say it isimpossible to know exactly how many athletes are doping, many observers believethe use of PESs by athletes is epidemic.[11, 12] However, some experts believe the current use of anabolic steroids and other synthetic hormones and blood substitutesmay soon become passe, because athletes may soon be able to inject genes to enhance performance and appearance. In the upcoming few decades, genetic engineering may profoundly alter the course of competitive sport by allowing scientists to create the“perfect” athlete, although risks for doing so may be high.[ 12] In fact, selected genetic engineering has already been achieved in animals.Researchers have shown in mice that a gene injected directly into a target muscle canincrease muscle performance by 27 percent.[13] More recently, researchers haveidentified a protein transcription factor, peroxisome proliferator-activated receptor-gamma coactivator-1, that, when expressed at physiologic levels in mice, converts
 
fast-twitch, strength muscles into high-endurance, slow-twitch muscles.[14] Somehave speculated that drugs that influence these factors may be used to increase muscleactivity, although much work still remains to elucidate the mechanism.[14,15] Combating the ProblemGiven previous attempts by the IOC to reduce and eliminate doping in sport, the prospects of halting the genetic engineering of athletes may be dim. As former IOC president Juan Antonio Samaranch said when he relinquished his position, “Indoping, the war is never won.”[16] In spite of this, we note that the recentestablishment of the WADA (and its counterpart in the United States, the US Anti-Doping Agency—USADA) offers for the first time a better coordinated andconsistent effort to combat doping in sport. In addition, drug education programs,especially those that target adolescent athletes, have the potential to change behavior and to be more cost-effective than further expanding drug testing programs. To date,however, WADA and USADA have been, at best, only marginally effective inovercoming the technological innovations of users and in reducing the prevalence of doping.Drug education programs, especially those that taaarget adolescent athletes, have the potential to change behavior and to be more cost-effective than it woulf be to further existing drug testing programs.
Questions to Ponder
It would be wonderful if athletes did not use PESs, but they do, and they are not goingto stop. As one writer observed, the genie is out of the bottle (and has been for a longtime), and there is no returning it. With so many athletes using PESs, perhaps thesesubstances should be legalized, at least in professional sports, thus leveling the playing field. Perhaps we should have two Olympic Games: one for athletes who aredrug-free and the other for athletes who use PESs.While sports play a significant role in our society and culture, the heart of the problem may be our overemphasis on winning. Winners become heroes as societycreates a culture that worships them. And, while some believe that all athletes arewinners just from competing, the fact is that an athletic competition produces onlyone first-place finisher—the winner. Not every athlete who competes wins, and for those lacking sufficient talent, PESs offer the means by which they may become“winners.” Too much fame and fortune can be gained by being a winner in sports toever think that the use of PESs will ever be completely eliminated.As witnessed by the continued television viewing of Major League Baseball gamesafter the new labor agreement's proposed, but weak, anabolic steroid testing program,fans don't appear that concerned about doping. If sport fans worldwide were polledand asked: “Are you upset by doping?” or “Are you against doping?” many, perhapseven a substantial majority, would say, “Yes.” However, a far more relevant questionis: “Are you upset enough about doping to turn off your television set and not watchsports?” Judging by the continuing profitability and popularity of both amateur and

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