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Chronic Kidney Disease

Chronic Kidney Disease

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Published by: sarguss14 on Jan 30, 2009
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07/06/2013

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CHRONIC KIDNEY DISEASE:
CHRONIC KIDNEY DISEASE:
Causes and Manifestations
Causes and Manifestations
Vimar A. Luz, MD, FPCP, DPSN
Vimar A. Luz, MD, FPCP, DPSN
DEFINITIONS
DEFINITIONS
Chronic renal disease (CRD)
Chronic renal disease (CRD) is a pathophysiologic
is a pathophysiologic
process (last more than 3 months) with multiple
process (last more than 3 months) with multiple
etiologies, resulting in the inexorable attrition of nephron
etiologies, resulting in the inexorable attrition of nephron
number and function, and frequently leading to end-
number and function, and frequently leading to end-
stage renal disease (ESRD).
stage renal disease (ESRD).
ESRD
ESRD represents a clinical state or condition in which
represents a clinical state or condition in which
there has been an
there has been anirreversible
irreversible loss of endogenous renal
loss of endogenous renal
function, of a degree sufficient to render the patient
function, of a degree sufficient to render the patient
permanently dependent upon renal replacement therapy
permanently dependent upon renal replacement therapy
(dialysis or transplantation) in order to avoid life-
(dialysis or transplantation) in order to avoid life-
threatening uremia.
threatening uremia.
DEFINITIONS
DEFINITIONS
Azotemia
Azotemia-
- refers to the retention of nitrogenous waste
refers to the retention of nitrogenous waste
products as renal insufficiency develops
products as renal insufficiency develops
Uremia
Uremia-
- is the clinical and laboratory syndrome,
is the clinical and laboratory syndrome,
reflecting dysfunction of all organ systems as a result of
reflecting dysfunction of all organ systems as a result of
untreated or undertreated acute or chronic renal failure.
untreated or undertreated acute or chronic renal failure.

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