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STRESS (BIOLOGICAL) FROM WIKIPEDIA Plus Some Information from a USACollege
From Wikipedia, the free encyclopedia(Redirected fromStress (medicine))
Stress
is a biological term which refers to the consequences of the failure of a human or animal body to respond appropriately toemotionalor physicalthreats to the organism, whether actual or imagined.
It includes a state of alarm and adrenaline production, short-term resistance as a copingmechanism, and exhaustion. It refers to the inability of a human or animal body torespond.
Common stress symptoms include irritability, muscular tension, inability toconcentrate and a variety of physical reactions, such as headaches and acceleratedheart rate.
The term "stress" was first used by theendocrinologist Hans Selyein the 1930s to identify physiological responses in laboratory animals. He later broadened and popularized theconcept to include the perceptions and responses of humans trying to adapt to thechallenges of everyday life.
In Selye's terminology, "stress" refers to the reaction of the organism, and "stressor" to the perceived threat.
Stress in certain circumstances may be experienced positively.Eustress(1), for example,can be an adaptive response prompting the activation of internal resources to meetchallenges and achieve goals.The term is commonly used by laypersons in a metaphorical rather than literal or biologicalsense, as a catch-all for any perceived difficulties in life. It also became a euphemism, away of referring to problems and eliciting sympathy without being explicitly confessional, just "stressed out".It covers a huge range of phenomena from mild irritation to the kind of severe problemsthat might result in a real breakdown of health. In popular usage almost any event or situation between these extremes could be described as stressful.[15]
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ModelsGeneral Adaptation Syndrome
Hans Selyeresearched the effects of stress
on rats and other animals by exposing themto unpleasant or harmful stimuli. He found that all animals presented a very similar seriesof reactions, broken into three stages. In 1936, he described this universal response to thestressors as the general adaptation syndrome, or GAS.
Alarm
is the first stage. When the threat or stressor is identified or realized, the body'sstress response is a state of alarm. During this stage adrenaline will be produced in order to bring about thefight-or-flight response. There is also some activation of theHPA axis,  producingcortisol.
Resistance
is the second stage. If the stressor persists, it becomes necessary to attemptsome means of coping with the stress. Although the body begins to try to adapt to thestrains or demands of the environment, the body cannot keep this up indefinitely, so itsresources are gradually depleted.
Exhaustion
is the third and final stage in the GAS model. At this point, all of the body'sresources are eventually depleted and the body is unable to maintain normal function. Atthis point the initialautonomic nervous systemsymptoms may reappear (sweating, raisedheart rate etc.). If stage three is extended, long term damage may result as the capacity of glands, especially the adrenal gland, and the immune system is exhausted and function isimpaired resulting in decompensation.
The result can manifest itself in obvious illnesses such asulcers,depression, diabetes, trouble with thedigestive systemor evencardiovascular problems, along with other mental illnesses.[edit
 
] Selye: eustress and distress
Hans Selyepublished in 1975 a model dividing stress intoeustressanddistress(2).
Where stress enhances function (physical or mental, such as through strength trainingor  challenging work) it may be consideredeustress. Persistent stress that is not resolvedthrough coping or adaptation, deemeddistress, may lead toanxietyor withdrawal (depression) behavior.
 
The difference between experiences which result in eustress or distress is determined bythe disparity between an experience (real or imagined), personal expectations, andresources to cope with the stress. Alarming experiences, either real or imagined, cantrigger a stress response.
 
] Lazarus: cognitive appraisal model
Lazarus
argued that in order for a psychosocial situation to be stressful, it must beappraised as such. He argued that cognitive processes of appraisal are central indetermining whether a situation is potentially threatening, constitutes a harm/loss, achallenge, or is benign.This primary appraisal is influenced by both person and environmental factors, andtriggers the selection of coping processes. Problem-focused coping is directed atmanaging the problem, while emotion-focused coping processes are directed at managingthe negative emotions. Secondary appraisal refers to the evaluation of the resourcesavailable to cope with the problem, and may alter the primary appraisal.In other words, primary appraisal also includes the perception of how stressful the problemis; realizing that one has more than or less than adequate resources to deal with theproblem affects the appraisal of stressfulness. Further, coping is flexible in that theindividual generally examines the effectiveness of the coping on the situation; if it is nothaving the desired effect, s/he will generally try different strategies.
 
] Neurochemistry and physiology
The neurochemistry of the stress response is now believed to be well understood,although much remains to be discovered about how the components of this systeminteract with one another, in the brain and throughout in the body. In response to astressor,corticotropin-releasing hormone (CRH) andarginine-vasopressin(AVP) are secreted into thehypophyseal portal systemand activate neurons of theparaventricular  nuclei(PVN) of thehypothalamus. Thelocus ceruleusand other noradrenergiccell groups of theadrenal medullaandpons, collectively known as the LC/NE system, also become active and use brainepinephrinetoexecute autonomic and neuroendocrine responses, serving as a global alarm system.
Theautonomic nervous systemprovides the rapid response to stress commonly known asthefight-or-flight response, engaging thesympathetic nervous systemand withdrawing the parasympathetic nervous system, thereby enacting cardiovascular, respiratory,gastrointestinal, renal, and endocrine changes.
 Thehypothalamic-pituitary-adrenal axis  (HPA), a major part of theneuroendocrine systeminvolving the interactions of thehypothalamus, thepituitary gland, and theadrenal glands, is also activated by release of  CRH and AVP.This results in release of adrenocorticotropic hormone(ACTH) from the pituitary into thegeneral bloodstream, which results in secretion of cortisoland other glucocorticoidsfrom theadrenal cortex. These corticoids involve the whole body in the organism's response tostress and ultimately contribute to the termination of the response via inhibitoryfeedback.
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