Dr Andrew Moulden MD, PhD © MASS BOOK Chapt.3:
M.A.S.S. M.A.Z.E. TRIAD
Thrombosis (blood clotting) is the result of alterations in blood flow stasis (pooling of blood),vascular endothelium injury (endothelial cells line the insides of all - blood vessel walls), oralterations in the constitution of the blood (hypercoagulability - propensity to form clots).The eponym “Virchow’s triad”, after German Physician Rudolf Virchow (1821-1902), is theterm used to capture these key components of blood clotting. Thrombosis is an integral part of tissue repair and healing. Thrombi (clots) can be large or microscopic. It is the microscopic clotsthat are causing autism-spectrum. The mechanism to injury, however, is a new medical discoverythat does not follow classic clotting pathways in physiology. I have called this process “M.A.S.S.–
yndromes.”The first category, alterations in normal blood flow, refers to several situations. These includeturbulence, stasis (low forward blood flow), blocked flow, varicose veins, the M.A.S.S. responseto vaccinations, infectious diseases, toxins, heavy metals, food, additives, and drugs to which anindividual is immunological hypersensitive to.The second category, injuries and/or trauma to endothelium includes damage to the vesselsarising from shear stress, hypertension, ischemia, toxins, metabolic derailments, and immunesystem responses to foreign substances in tissue, the blood, or the blood vessel walls themselvesThe last category, alterations in the constitution of blood, emerges from numerous possible risk factors such as hyper viscosity, deficiency of antithrombin III, protein C & S, renal (kidney) andhepatic (liver) impairment, changes after severe trauma, estrogen levels, disseminated cancer,late pregnancy and delivery, race, age, whether the patient is a smoker, obese, diabetic, andheavy metal ion exchanges that lower Zeta potentials… to name a few. Any and all of thesefactors increase the risk for hypercoagulability which is an increased tendency to form bloodclots. The clots formed may be large or microscopic.If blood clots occupy greater than 75% of a the inside diameter of a blood vessel, then oxygendelivery is impaired and the risk for stroke is increased. Ischemic stroke is a generic term whichconnotes oxygen demand exceeding oxygen supply and can happen ANYWHERE in the bodyand not just the brain. For example, strokes in the large bowel caused by an inflammation resultsin ischemic colitis and autistic enterocolitis. Ischemia in the small bowel that is caused byinflammation, results in mesenteric ischemia. Gluten plays a role in these ischemic processesafter MASS via ischemia reperfusion injuries. After MASS has damage bowel microcirculationunits, any gastrointestinal inflammatory response can re-trigger bowel symptoms.