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Malecot's method of coancestry

Malecot's method of coancestry

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Published by Paul Muljadi
Malecot's method of coancestry
Malecot's method of coancestry

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Published by: Paul Muljadi on Dec 28, 2012
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12/28/2012

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Malecot's method of coancestry1
Malecot's method of coancestry
Malecot's coancestry coefficient
, , refers to an indirect measure of genetic similarity of two individuals whichwas initially devised by the French mathematician Gustave Malécot.is defined as the probability that any two alleles, sampled at random (one from each individual), are identicalcopies of an ancestral allele. In species with well-known lineages (such as domesticated crops), can be calculatedby examining detailed pedigree records. Modernly, can be estimated using genetic marker data.
Evolution of inbreeding coefficient in finite size populations
In a finite size population, after some generations, all individuals will have a common ancestor : . Considera non-sexual population of fixed size , and call the inbreeding coefficient of generation . Here, meansthe probability that two individuals picked at random will have a common ancestor. At each generation, eachindividual produces a large number of descendants, from the pool of which individual will be chosen atrandom to form the new generation.At generation , the probability that two individuals have a common ancestor is "they have a common parent" OR"they descend from two distinct individuals which have a common ancestor" :This is a recurrence relation easily solved. Considering the worst case where at generation zero, no two individualshave a common ancestor,, we getThe scale of the fixation time (average number of generation it takes to homogenize the population) is thereforeThis computation trivially extends to the inbreeding coefficients of alleles in a sexual population by changing to(the number a gametes).
References
Malécot G.
 Les mathématiques de l'hérédité.
Paris: Masson & Cie, 1948.

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