Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Download
Standard view
Full view
of .
Save to My Library
Look up keyword
Like this
1Activity
0 of .
Results for:
No results containing your search query
P. 1
Caries Vaccine

Caries Vaccine

Ratings: (0)|Views: 49 |Likes:
Published by Rajesh Kumar

More info:

Published by: Rajesh Kumar on Dec 28, 2012
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PPT, PDF, TXT or read online from Scribd
See more
See less

07/04/2013

pdf

text

original

 
Dental Caries
Vaccines
An update
 
Caries vaccines
The evidence of a specific bacterial cause of dental caries and the function of salivary glands asan effector site of the mucosal immune system hasprovided a scientific basis for developing avaccine against this highly prevalent and costlyoral disease.
Research for a safe and effective vaccine wasfacilitated by: progress in molecularbiology(cloning virulence factors of S.mutans), inmucosal immunology(sophisticated Ag deliverysystem,adjuvants stimulating IgA Ab response)
 
Evidence for S.Mutans as the major bacterial etiologic factor in human dentalcaries
It can almost always be isolated from plaque.
Most carious lesions have >10% S. Mutans.
Most non-infected areas are non-carious.
Longitudinal studies show S. Mutans precedesdevelopment of dental caries.There are studies showing that children who do notbecome infected in the first 3 years of life,appearto remain uninfected for several years, possiblyuntil a new opportunity for colonization occursupon eruption of the secondary dentition.

You're Reading a Free Preview

Download
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->