Description

ISBN: 0-471-08314-3 (0471083143)

CENTRAL ANALGETICS -- Chemistry & Pharmacology of Drugs (vol. 1)

The 1982 text "Central Analgetics" is another great contribution from Daniel Lednicer to the organic & medicinal chemistry community. If you enjoyed Lednicer's "The Organic Chemistry of Drug Synthesis" series, you will also enjoy this comprehensive review of the organic chemistry of opioid synthesis & their structure-activity relationships.
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FROM THE PREFACE:

Chemistry and Pharmacology of Drugs is a series of books intended to allow scientists involved in drug development to become familiar with specific therapeutic areas by consulting a single volume devoted specifically to that area.

A description of the organic and medicinal chemistry of central analgetics forms the last chapter of this book. In this section, Lednicer describe in some detail the chemistry and structure activity relationships of the more important classes of opioids developed to date. The discussion goes beyond agents used in the clinic in order to illustrate salient points on the evolving concept of the SAR of these agents. A critical review of SAR, as used to carry out receptor mapping in the opioid series, has been included.
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CHAPTERS:

(1) PAIN PATHWAYS: POTENTIAL SITES FOR ANALGETIC ACTION -- J. Scott Mohrland

(2) PHARMACOLOGICAL ALTERATION OF PAIN: THE DISCOVERY AND EVALUATION OF ANALGETICS IN ANIMALS -- Philip F. VonVoigtlander

(3) THE POTENTIAL OF CENTRALLY ACTING REGULATORY PEPTIDES AS ANALGETICS -- John S. Motley

(4) MEDICINAL CHEMISTRY OF CENTRAL ANALGETICS -- Daniel Lednicer