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Enzymes Lock & Key Hypothesis

Enzymes Lock & Key Hypothesis

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Published by Bio_Joe
Student discussion activity about the lock and key hypothesis of enzyme action. Which is the lock, which is the key?
Student discussion activity about the lock and key hypothesis of enzyme action. Which is the lock, which is the key?

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Published by: Bio_Joe on Jan 16, 2013
Copyright:Attribution Non-commercial

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07/10/2013

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Nicola Perscheid [Public domain], via Wikimedia Commons
 
Enzymes
 
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Who’s this dude?
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Hermann Emil Fischer.
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Never heard of him.
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He won the Nobel Prize in 1902.
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OK That’s prey cool. Why?
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For his work on sugar and purine synthesis.
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Nice… But the tle of this sheet is enzymes.
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Yeah, he also worked with them too. In 1894 he wrote:
 
“Um ein Bild zu gebrauchen, will ich sagen, dass Enzym und Glucosid wie Schlossund Schlüssel zu einander passen müssen, um eine chemiache Wirkung auf einander ausüben zu können.”
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I don’t speak German.
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Fine. I’ll translate:
 
“To give an illustraon I will say that enzyme and glucoside must t together likelock and key in order to be able to exercise a chemical acon on each other.
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So he came up with the ‘lock & key hypothesis’, nice… Queson: Is the enzymethe lock or the key?
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Not sure...
 

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