•
PDA
The aortic end of the ductus is just distal to the origin of the
left subclavian artery
, and the ductus enters the
pulmonary artery at its bifurcation
. Commonly associated with
maternal rubella infection
during early pregnancyand
preterms
as a result of
hypoxia
and
immaturity
. Closes in the
1
st
weeks of life
failure to which there is
↑
bloodflow to the lungs
→
pulmonary plethora
& congestion
→
fibrosis of the vessels with narrowing & reduced blood flowto the lungs leading to
cyanosis.C/P:
-
Persistent apnoea for unexplained reasons in an infant recovering from Hyaline Membrane Disease;
-
CVS
*
Collapsing pulse
*
'Pistol shot' pulse in the femorals (Traube's Sign)
*
Wide pulse pressures
*
Reversed splitting of P
2
*
An active heaving praecordium, a
continuous systolic
or
to-and-fro murmur
that may be localizedto the
2
nd
left ICS
or
radiate
down the left sternal border
or to
the left clavicle
-
Carbon dioxide retention - Cyanosis
-
Increasing oxygen dependency
-
Hepatomegaly
CXR
- Cardiomegaly and increased pulmonary vascular markings
Echocardiographic
visualization of a PDA with Doppler flow evidence of left-to-right shunting.
Rx:
-
Supportive measures, including
diuretics and fluid restriction.
-
If spontaneous closure does not occur within a few weeks post partum;
*
Indomethacin IV, 0.2 mg/kg BD/OD - 3 doses
;
induces pharmacologic closure by inhibiting prostaglandin synthesis.
OR
0.1 mg/kg/d for 6 days
.Contraindications to indomethacin:- Thrombocytopenia (<50,000/mm
3
),- Bleeding disorders- Oliguria (
<0.5ml/kg/d
)- Elevated plasma creatinine level (
>80µmol/L
)- Necrotizing enterocolitis (NEC)
-
Indications for
surgical closure
are
failure to close the ductus following indomethacin therapy
with
persistent heart failure
and
ventilator dependence
.
•
RAE
-
P pulmonale - Peaked P waves
•
LAE
-
P mitrale - Bifid P waves
•
ASD
-
Left parasternal heave
-
Wide fixed splitting of P
2
•
Atrial fibrillation
-
Irregularly irregular
pulse
-
Absent a wave
-
Absent P wave with Irregularly irregular QRS complexes
•
Atrial flutter
-
Regularly
Irregular
pulse
-
'Canon' a waves
-
Saw tooth baseline (300/s) with
Regular
QRS complexes
•
RVH
-
Left parasternal heave
-
Dominant RV
1
-
Deep SV
6
-
T wave inversion in V
1
-V
3/4
-
RAD
-
QRS enlargement
Medicine Page 2