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LONG
®
R
3
IGF-I
 Your insulin alternative
www.sacbiosciences.com
 
LONG
®
R
3
IGF-I
 Your insulin
 
alternative
Independent analysis o LONG
®
R
3
IGF-I in cell cultureCompany Benet Reerence
Immunex
LONG
®
R
3
IGF-I resulted in higher Morris
et al 
, Biotechnology Progress,CHO cell growth and viability. 2000, 16, 693-697. Abgenix
LONG
®
R
3
IGF-I resulted in higher Chun
et al 
, Biotechnology Progress,CHO cell growth, viability and eased 2003, 19, 52-57.adaptation to serum-ree media.Seattle Genetics
LONG
®
R
3
IGF-I resulted in Sundra
et al 
, Seattle Genetics, Cellmaintaining higher CHO cell Culture Engineering 10th annual meeting.viability and extended culture duration.University o 
LONG
®
R
3
IGF-I resulted in Buckler
et al 
, University o Birmingham,Birmingham, UK higher HEK 293 growth and JAACT 19th annual meeting.maintained higher culture viability.
Proven science to maximizecell culture perormance
When
LONG
®
R
3
IGF-I is supplementedinto serum-ree media it promotes cellprolieration, increased cell survival,increased productivity through greaterprolieration and anti-apoptoticsignaling.
LONG
®
R
3
IGF-I providesequivalent or better perormance torecombinant insulin depending on thecell line and clone.
LONG
®
R
3
IGF-I has been usedsuccessully with numerous cell typesincluding CHO, BHK, HEK 293, Vero,PER.C6
®
, MDCK and broblasts (graphs1-4 page 4). All cell types that havea growth response to insulin in cellculture have the potential to respond to
LONG
®
R
3
IGF-I.
A growth actor manuacturedexclusively or industrial cellculture
Recombinant human insulin and othergrowth actors are essential or long-termgrowth and prolieration o cell lines. Although insulin is used as a growthactor in cell culture, its primary use isas a therapeutic drug or the treatmento diabetes. This has led to supply andavailability issues or industrial cellculture users. In contrast,
LONG
®
R
3
IGF-I isa dedicated raw material manuacturedexclusively or cell culture applicationsproviding a consistent, compliant andreliable alternative to recombinantinsulin. It is not subject to marketfuctuations and shortages as isrecombinant insulin.
 
LONG
®
R
3
IGF-I
is notsubject to market fuctuationsand shortages as isrecombinant insulin.
LONG
®
R
3
IGF-I is a highlypotent and eectivealternative to recombinantinsulin or cell cultureapplications. It has beenengineered specicallyor supplementation o serum-ree cell culturemedia to enhance thesurvival and prolierationo mammalian cells.
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