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Dr Nadine Gravett School of Anatomical Sciences Room 2B10B Tel: (011) 717 2212 Nadine.Gravett@wits.ac.za
OBJECTIVES
Classify, identify and describe the histological structure and function of:
Simple squamous, cuboidal and columnar epithelia with various surface modifications Stratified squamous epithelium (keratinized and nonkeratinized) Pseudostratified columnar epithelium with various surface modifications Transitional epithelium
Overview
Avascular tissue composed of closely apposed cells Where do we find epithelium?
Cover exterior body surfaces External and internal linings of organs
Mesothelium Endothelium
OVERVIEW
Characteristics: Closely apposed Avascular Polarity
Apical, Lateral and Basal surfaces
Functions:
Creates a SELECTIVE BARRIER Protection Absorption Filtration Lubrication Excretion Secretion Sensory reception
Rest on basal lamina/basement membrane Regeneration Very little extracellular substance Derived from all 3 embryonic layers
CLASSIFICATION
Based on:
1. Number of cell layers
Simple 1 layer Stratified more than 1 layer
www.lab.anhb.uwa.edu.au/mb140/
If you cant make out a distinct cell shape look at the NUCLEUS!!!!
SQUAMOUS EPTIHELIUM
SIMPLE STRATIFIED
www.lab.anhb.uwa.edu.au/mb140/
Epidermis
www.lab.anhb.uwa.edu.au/mb140/
CUBOIDAL EPITHELIUM
SIMPLE STRATIFIED
Ross and Pawlina (2011). Histology: A text and Atlas, 6th edt
COLUMNAR EPTHELIUM
SIMPLE
STRATIFIED
www.lab.anhb.uwa.edu.au/mb140/
SPECIAL CLASSIFICATIONS
PSEUDOSTRATIFIED EPITHELIUM
www.lab.anhb.uwa.edu.au/mb140/
TRANSITIONAL EPITHELIUM
www.lab.anhb.uwa.edu.au/mb140/
CELL POLARITY
Specializations:
Microvilli Stereocilia Cilia
Specializations:
Occluding jnxs Anchoring jnxs Communicating jnxs Plicae (morphological)
Specializations:
BM Cell to ECM jnxs Membrane infoldings
http://www.zimbio.com/member/kasya30/articles/1m2sr2-ZOk-/animal+cell+diagram+labels
EM
Function:
Increases surface area for absorption
Jejunum LM
Movement:
Passive
Function:
Absorption Mechanoreception
www.lab.anhb.uwa.edu.au/mb140/
Movement:
Active
Function:
Movement of fluid or suspended matter in one direction
INTERCELLULAR JUNCTIONS
Functions as:
1. Seals
Prevent flow of materials between cells E.g. Occluding junctions (a.k.a. Tight junctions)
2. 3.
Site of adhesion
E.g. Adhesive/Anchoring junctions
csls-text.c.u-tokyo.ac.jp/active/11_04.html
Ross and Pawlina (2011). Histology: A text and Atlas, 6th edt
Ross and Pawlina (2011). Histology: A text and Atlas, 6th edt
www.mun.ca/biology/desmid/brian/BIOL2060/BIOL2060-17/CB17.html
Ross and Pawlina (2011). Histology: A text and Atlas, 6th edt
Macromolecular components:
Laminin, Type IV collagen, Entactin (GP) and Perlecan (PG) as well as several other GPs and PGs
Increase cell surface area of basal domain In the cells that participate in active transport (proximal and distal tubules of kidney) Ducts of salivary glands
Ross and Pawlina (2011). Histology: A text and Atlas, 6th edt
REFERENCES
Ross and Pawlina (2011). Histology: A text and Atlas, 6th edt Mesher, A.L. Junqueiras Basic Histology. Text and Atlas, 12th edt