Topic 1: The Use of IT and/or Social Media to Promote Health
Technological advances in areas such as mobile communications have brought handheld and web-basedinteraction (through the use of smartphones, via social media, etc) to a majority of people in the US.Hypothetically, these modes of communication hold potential for the delivery of personalizedmedicine/behavioral health interventions, personalized data collection and self/provider monitoring of healthbehaviors. Ultimately, these types of interactions may lead to improved health behaviors and clinicaloutcomes.The utility, effectiveness and clinical implementation of these technologies in the area of health behavior change have not been extensively researched. Therefore, we invite proposals that address this emerging areaof research and healthcare.Examples of potential areas of interest include:
Smartphone apps for patient self-monitoring of health behaviors and/or interventions to support behavior change.
Web-based patient/health professional communication (e-medicine).
Development and testing of patient support for healthy behaviors via web or mobile phone.
Patient educational tools via web or mobile app/phone communication.
Clinical implementation of web or mobile phone tools for patient and/or provider utilization in providingpersonalized medicine.
Topic 2: Personalized Medicine Policy and Implementation Science
Implementation science, or the study of effectiveness, efficiency, and equity of health program selection, delivery,and uptake in real-world settings, is facilitating the practice of personalized health care in diverse settings,including primary and specialty clinics, health systems, and community-based programs. However, the adoptionof personalized health care into clinical settings has not been without its challenges. One barrier to wideimplementation of personalized health care has been the dearth of process data, and the policy implicationsstemming from these data, which can provide applicable, generalizable support for the translation of knowledge
policymakers for policy development, which supports or allows for personalized health care applications to be used andfeasible across diverse sites.Therefore, one of the foci of this RFA is health policy and regulatory implications for personalized health careimplementation in clinical or community sites. For purposes of this RFP, policy includes all levels from individualpractice sites to health systems to state/federal. Proposed studies can explore policy issues related toimplementation of personalized health care or generate evidence to inform policy that supports real worldimplementation of personalized health care into clinical settings.Examples include:
Exploration of provider understanding regarding public policies that would affect implementation of pharmacogenomic testing (or other personalized health care strategies) in clinical practice.
Analysis of policies and processes required for effective collection of personalized patient entered data(i.e., psychosocial/behavioral data) in EMR.
impact its role in health care delivery.
and its potential role in their health and health care.
Examination or survey of economic or policy barriers to implementation of personalized medicine in ahealth system or broader health care arena.
Topic 3: Adoption of Personalized Medicine Concepts and Paradigms in the Clinical Setting.
There are several barriers that stand in the way of widespread adoption of personalized medicine.First, clinicians are slow to adopt new paradigms for care, in particular those that involve assessing risk or incorporation of new information that has to be integrated into established practice patterns and decision making. Adoption is further hindered when the information is unfamiliar, e.g. genetic information.Second, in a rapidly changing healthcare environment, it is likely that many of the personalized medicinerecommendations will take some time to get into guidelines and therefore supported by practice incentives.