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Center for Personalized Medicine Pilot Project RFA

Center for Personalized Medicine Pilot Project RFA

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Duke's Center for Personalized Medicine is requesting applications for multidisciplinary pilot studies in four areas of personalized medicine.
Duke's Center for Personalized Medicine is requesting applications for multidisciplinary pilot studies in four areas of personalized medicine.

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Published by: Duke Department of Medicine on Feb 06, 2013
Copyright:Attribution Non-commercial


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1 2.1.2013
Request for Applications
Pilot Studies
This announcement introduces a funding opportunity for multidisciplinary, collaborative pilot projects that willexplore personalized medicine topics in the context of Duke Medicine. For this announcement, personalizedmedicine means the application of proven medical interventions or therapies that are individualized topatient characteristics or preferences. The members of the Center for Personalized Medicine (CPM) havebeen working toward elucidating personalized medicine outcomes, including clinical, personal, behavioral,economic and patient satisfaction outcomes, at the patient, provider, practice, and health systems level.The CPM is interested in receiving proposals that address one or more of the following four topics within thefield of personalized medicine (a full description of each topic and examples follow these guidelines):- Use of IT and/or Social Media To Promote Health- Policy and Implementation- Adoption of Personalized Medicine Concepts and Paradigms in the Clinical Setting- Personalized Medicine
EducationUp to 4 projects will be funded at a level of up to $50,000 each, pending the receipt of appropriateproposals. There is no guarantee of an award within each topic category. The review will occur in twostages, with preliminary proposals accepted from the date of this announcement until
5 PM, Monday, March18
. Notification and request for full proposals will be made in April. Final awards will be announced in May,with earliest anticipated funding of June, 2013.Preliminary/concept proposals,
two (2) pages plus rough budget,
should include the following details:- The specific question to be addressed;- The application to personalized medicine;- The collaborative multidisciplinary nature of the project with detail about the contributingresearchers/groups;- The potential for long term sustainability and funding once the goals of the project are completed.Full proposals,
five (5) pages maximum, plus a detailed budget
, will require more detail on these items,as well as study methods.Formatting guidelines: minimum of Arial font 11 or equivalent and 1 inch marginsTo meet the abovementioned goals, proposals should:1. Be carried out by a multidisciplinary team of Duke personnel (we encourage collaboration frommultiple schools within Duke)2. Specifically detail how the research addresses the definition of personalized medicine:
An integrated evidence-based approach to patient care across the continuum (from health to disease), using multidisciplinary teams to promote health and wellness, patient education,empowerment, and satisfaction, and to use the innovative tools to customize disease prevention,detection, and treatment 
 3. Address at least one of the above topics4. Be designed to generate preliminary data as a basis for follow on funding; and state explicitly whatsources of follow on funding will be sought.
Application should be addressed to:
Center for Personalized Medicine Research Committeec/o Teji Rakhra-BurrisEmail:teji.rb@duke.edu 
2 2.1.2013
Topic 1: The Use of IT and/or Social Media to Promote Health
Technological advances in areas such as mobile communications have brought handheld and web-basedinteraction (through the use of smartphones, via social media, etc) to a majority of people in the US.Hypothetically, these modes of communication hold potential for the delivery of personalizedmedicine/behavioral health interventions, personalized data collection and self/provider monitoring of healthbehaviors. Ultimately, these types of interactions may lead to improved health behaviors and clinicaloutcomes.The utility, effectiveness and clinical implementation of these technologies in the area of health behavior change have not been extensively researched. Therefore, we invite proposals that address this emerging areaof research and healthcare.Examples of potential areas of interest include:
Smartphone apps for patient self-monitoring of health behaviors and/or interventions to support behavior change.
Web-based patient/health professional communication (e-medicine).
Development and testing of patient support for healthy behaviors via web or mobile phone.
Patient educational tools via web or mobile app/phone communication.
Clinical implementation of web or mobile phone tools for patient and/or provider utilization in providingpersonalized medicine.
Topic 2: Personalized Medicine Policy and Implementation Science
Implementation science, or the study of effectiveness, efficiency, and equity of health program selection, delivery,and uptake in real-world settings, is facilitating the practice of personalized health care in diverse settings,including primary and specialty clinics, health systems, and community-based programs. However, the adoptionof personalized health care into clinical settings has not been without its challenges. One barrier to wideimplementation of personalized health care has been the dearth of process data, and the policy implicationsstemming from these data, which can provide applicable, generalizable support for the translation of knowledge
policymakers for policy development, which supports or allows for personalized health care applications to be used andfeasible across diverse sites.Therefore, one of the foci of this RFA is health policy and regulatory implications for personalized health careimplementation in clinical or community sites. For purposes of this RFP, policy includes all levels from individualpractice sites to health systems to state/federal. Proposed studies can explore policy issues related toimplementation of personalized health care or generate evidence to inform policy that supports real worldimplementation of personalized health care into clinical settings.Examples include:
Exploration of provider understanding regarding public policies that would affect implementation of pharmacogenomic testing (or other personalized health care strategies) in clinical practice.
Analysis of policies and processes required for effective collection of personalized patient entered data(i.e., psychosocial/behavioral data) in EMR.
impact its role in health care delivery.
and its potential role in their health and health care.
Examination or survey of economic or policy barriers to implementation of personalized medicine in ahealth system or broader health care arena.
Topic 3: Adoption of Personalized Medicine Concepts and Paradigms in the Clinical Setting.
There are several barriers that stand in the way of widespread adoption of personalized medicine.First, clinicians are slow to adopt new paradigms for care, in particular those that involve assessing risk or incorporation of new information that has to be integrated into established practice patterns and decision making. Adoption is further hindered when the information is unfamiliar, e.g. genetic information.Second, in a rapidly changing healthcare environment, it is likely that many of the personalized medicinerecommendations will take some time to get into guidelines and therefore supported by practice incentives.

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