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Table Of Contents

1. Introduction
1.1. Molecular Structure
2. Biosynthesis
2.1. Overview
2.2. Overall Chemical Equation
2.3. Biosynthetic Gene Clusters
2.4. Regulation of Biosynthesis
2.4.1. Role of Oxygen
2.4.2. Role of Carbon Metabolism
2.4.3. StrR-like Regulation
2.5. Biosynthesis of Nonproteinogenic Amino Acid Monomers
2.5.1. 4-Hydroxyphenylglycine
2.5.2. 3,5-Dihydroxyphelylglycine
2.5.3. β-Hydroxytyrosine
2.6. Nonribosomal Peptide Synthases
2.6.1. General Module Structure
2.6.1.1. Activation Domain
2.6.1.2. Peptidyl Carrier Protein Domain
2.6.1.3. Condensation Domain
2.6.1.4. Epimerizing Domain
2.6.1.5. Thioesterase Domain
2.6.2. Vancomycin Group NRPS Machinery
2.7. Peptide Modifications
2.7.1. Halogenation
2.7.2. Cross-linking of Residues 2-4-6 and 5-7
2.7.3. N-terminus Methylation
2.7.4. Glycosylation
2.7.4.1. Unusual Monosaccharide Biosynthesis
2.7.4.2. Glycosyl Transferases
2.8. Glycopeptide Export
3. Mechanism of Action
3.1. Molecular Target
3.1.1. Cell Wall Structure & Synthesis
3.2. Primary Mode of Action
3.3. Mechanism of Cell Death
4. Vancomycin Resistance
4.1. Molecular basis for Resistance
4.2. Proteins Conferring Resistance
4.3. Genes Conferring Resistance
5. Improving on Nature’s Design
5.1. Oritavancin
6. Conclusion
References
P. 1
Vancomycin Group Antibiotics

Vancomycin Group Antibiotics

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Published by sukarian

Vancomycin Group Antibiotics

Vancomycin Group Antibiotics

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categoriesTypes, Research, Science
Published by: sukarian on Feb 21, 2013
Copyright:Attribution Non-commercial
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09/17/2013

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