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4-Amino-4-arylcyclohexanones. 1. Modification of the aryl ring. Lednicer, J Med Chem, 23, 424 (1980)

 
 
 
 
 
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4-(p-Bromophenyl)- 4-(dimethylamino)- 1-phenethylcyclohexanol (BDPC)

C-8813

1. Lednicer D, VonVoigtlander PF, Emmert DE. 4-amino- 4-arylcyclohexanones and their derivatives: a novel class of analgesics. 2. Modification of the carbonyl function. Journal of Medicinal Chemistry. 1981 Apr;24(4):404-8.

PMID 7265128

2. Lednicer D, VonVoigtlander PF. 4-(p-Bromophenyl)-4-(dime thylamino)-1-phenethylcyc lohexanol, an extremely potent representative of a new analgesic series. Journal of Medicinal Chemistry 1979; 22(10):1157-1158.

PMID 513062

3. ^ Daniel Lednicer. 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use.
US Patent 4366172

4. Liu ZH, Jin WQ, Dai QY, Chen XJ, Zhang HP, Chi ZQ. Opioid activity of C8813, a novel and potent opioid analgesic. Life Sciences. 2003 May 30;73(2):233-41.

PMID 12738037

5. Martin J, Andrews P. Conformation-activity relationships of opiate analgesics. Journal of Computer-Aided Molecular Design. 1987 Apr;1(1):53-72.

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02/19/2009

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