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Biomaterials - Material Matters v3n3

Biomaterials - Material Matters v3n3



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Published by Sigma-Aldrich
Antifouling PEG Coatings
Layer-by-Layer (LbL) Assembly
“Click” Chemistry in (Bio)Materials Science
Chemistry at Surfaces with Self-Assembled Monolayers
Bone Tissue Engineering
Antifouling PEG Coatings
Layer-by-Layer (LbL) Assembly
“Click” Chemistry in (Bio)Materials Science
Chemistry at Surfaces with Self-Assembled Monolayers
Bone Tissue Engineering

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Published by: Sigma-Aldrich on Feb 20, 2009
Copyright:Attribution Non-commercial


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Aldrich Chemical Co., Inc.Sigma-Aldrich Corporation
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Material Matters
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Attn: Marketing CommunicationsAldrich Chemical Co., Inc.Sigma-Aldrich CorporationP.O. Box 355Milwaukee, WI 53201-9358
International customers, please contact yourlocal Sigma-Aldrich ofce. For worldwide contactinormation, please see back cover.
Material Matters
is also available in PDF ormat onthe Internet at
.Aldrich brand products are sold throughSigma-Aldrich, Inc. Sigma-Aldrich, Inc. warrants thatits products conorm to the inormation contained inthis and other Sigma-Aldrich publications. Purchasermust determine the suitability o the product or itsparticular use. See reverse side o invoice or packingslip or additional terms and conditions o sale.All prices are subject to change without notice.
Material Matters
(ISSN 1933–9631) is a publication o Aldrich Chemical Co., Inc. Aldrich is a member o theSigma-Aldrich Group. © 2008 Sigma-Aldrich Co.
Vol. 3 No. 3
   I  n   t  r  o   d  u  c   t   i  o  n
About Our Cover
Researchers are developing new methods or the preparation o biomaterials that unction to improveproperties o biomedical devices. Layer-by-Layer sel-assembly (LbL), described in the article on page57, is a useul method or making thin ilms o unctional biomaterials. In the LbL technique, alternatelayers o oppositely charged polymers are solution deposited to orm multilayered ilms (see illustrationon cover) on suraces o biomedical devices (e.g. stents), or walls o controlled-release capsules (pills).Charged drugs or biological molecules (proteins, DNA) can be incorporated into the LbL ilms. Forexample, cationic poly(diallylammonium chloride) shown on the cover can be co-deposited with anionicDNA; the ilms can release encapsulated DNA, working as vehicles or gene delivery. See the producttable on page 60 or a list o polymers or LbL applications.
Welcome to the third 2008 issue o
Material Matters
ocusing on Biomaterials, aresearch area that deals with synthetic and natural materials used in contact withbiological systems. The ield o biomaterials is interdisciplinary and encompasses aspectso materials science as well as chemistry, biology, and medicine. It has a unique “human”aspect: ew other areas o materials research can have equally direct impact on thequality o human lives by advancing medical care and diagnostics. Some results obiomaterials research are already implemented in medical practice. For example, steadyresearch progress made over the last 50 years in structural biomaterials lead to signiicantimprovements in quality o dental implants and artiicial hip joints. Other aspects obiomaterials research are just starting to aect our lives. Novel polymeric biomaterialswhich encapsulate and control release rate release o drugs are used to design “high-tech” pills and to coat suraces o cardiovascular implants. More advanced biomaterialsapplications are shaping on the research horizon: tissue engineering scaolds, genedelivery devices, and biochips designed to customize medical care to an individualpatient’s genotype are some areas o active research.Modern biomaterials are becoming complex, and present challenges both in termso preparation (synthesis, abrication, processing) o new material types, as well asanalyses o inished biomaterials and their interactions with biological systems. In thisissue, researchers rom the Northwestern University describe new methods to preparebiomaterial suraces resistant to ouling by biomolecules and bioorganisms. Layer-by-layer sel-assembly, an innovative and versatile approach to prepare thin ilms ounctional biomaterials, is described in the article written by Drs. Ariga and Hill romthe Japan’s National Institute or Materials Science. In their article on p. 57, researchersrom the University o Nijmegen and Encapson B.V., Netherlands, discuss the applicationo “click” chemistry to make designer macromolecules that can be used as buildingblocks or controlled, bottom-up preparation o biomaterials. In the area o biomaterialscharacterization, Proessor Mrksich rom the University o Chicago describes SAMDI-TOF,a surace-sensitive mass spectrometry technique that can be used to measure detailedchemical composition o, or example, biochip suraces. Finally, Proessors Huster andPretzsch rom the University o Leipzig, Germany, write about application o solid stateNMR to characterize engineered bone tissue — a very complex unctional biomaterialcentral to current eorts in regenerative medicine.Customary to
Material Matters
, each article in this issue is accompanied by a list oSigma-Aldrich
products helpul in the corresponding kind o biomaterials research.We at Sigma-Aldrich are pleased to combine our global expertise in high technology andlie science to bring you a set o interdisciplinary tools or biomaterials research, whichcan be ound at
. I you think we can improve thispage or add another set o products helpul or your work, email us at
.Ilya Koltover, Ph.D.Aldrich
Materials ScienceSigma-Aldrich
For questions, product data, or new product suggestions, please contact Aldrich Materials Science at
Joe Porwoll, PresidentAldrich Chemical Co., Inc.
I  n t  o d  u c  t i   on
Do you have a compound that you wish Sigma-Aldrich
could list to help materials research?If it is needed to accelerate your research, it matters—please send your suggestion to
and we will be happy to give it careful consideration.
“Your Materials Matter.”
Proessor Annelise Barron o Stanord University kindlysuggested that we oer
-hydroxyethyl acrylamide (HEAA),a monomer which can be used to make polymers that areuseul as wall coatings and separation media or lab-on-a-chip devices. Hydrophilic poly-
-hydroxyacrylamide (pHEAA),synthesized by ree radical polymerization o HEAA in water,orms a stable adsorbed coating on glass and used silicamicrochannels, enabling excellent biomolecule separations.pHEAA coatings eliminate electroosmotic low and greatlyreduce non-specic adsorption o biomolecules to the internalwalls o microluidic channels. DNA ragments o > 500bases have been successully separated and sequenced usingpHEAA-assisted microcapillary electrophoresis.
(1) Albarghouthi, M.N., Buchholtz, B.A., Huiberts, P.J., Stein, T.M.,Barron, A.E.
, 1429.(2) Fredlake, C.P., Hert, D.G., Kan, C.W., Chiesl, T.N., Root, B.E., Forster,R.E., Barron, A.E.
Proc. Natl. Acad. Sci. USA
, 476.
-Hydroxyethyl acrylamide (HEAA), 97%
697931-100ML100 mL25.00
-Hydroxyethyl acrylamide — Tool for Lab-On-A-Chip Research
Biomaterials Featured in This Issue
Materials CategoryContentPage
Functionalized PEGsMonounctional, homobiunctional and heterobiunctional poly(ethylene glycol)polymers54, 65PolyelectrolytesAnionic and cationic polymers used in layer-by-layer (LbL) sel-assembly60Click-Compatible BiomaterialsAzide and alkyne unctionalized polymers65Polymersome-orming polymersAmphiphilic block copolymers
Materials or Molecular Sel-AssemblyAlkyl-thiols or making sel-assembled monolayers (SAMs) on gold70Biocompatible CeramicsMetal oxide ceramic particles commonly used in biomaterials and biomedical research74Biocompatible MetalsTitanium wires, rods, oils, and sponges75

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