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 Telomeres - the physical ends of chromosomeGreek root: telos (end), mere (part)I. Functional definition of a telomereFirst defined functionally, long before molecular details were known Two essential functions in cellsA. Protection1930’s genetic and cytological analysisQuestion: What happens if you introduce a break into the chromosome?Muller: x-rays in drosophilaMcClintock: dicentrics in cornResult: the end is sticky and will readily fuse to another broken endConclusion: Telomere is protective cap
 
McClintock
 
B. Replication Two theoretical papersWatson 1972Olovnikov 1973 The end replication problem
Greider 1995
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